Disconnection of alpha oscillations within default mode network associated with memory dysfunction in amnestic MCI

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-09-17 DOI:10.1016/j.clinph.2024.09.010

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Abstract

Objective

Episodic memory dysfunction and alterations of functional connectivity (FC) in default mode network (DMN) were found in patients with amnestic mild cognitive impairment (aMCI). However, previous studies were limited in probing certain oscillations within the DMN. This study employed measures of resting-state FC across various oscillations within the DMN to comprehensively examine the FC and its association with episodic memory performance in aMCI.

Methods

Twenty-six healthy controls (HC) and 30 patients with aMCI were recruited to perform resting-state magnetoencephalographic recordings. We compared the spectral powers and peak frequency values in each frequency band and FC within the DMN between these two groups. The associations of FC values with memory performance were also examined.

Results

No significant between-group differences in spectral powers and peak frequency values were observed in the regional nodes. Patients with aMCI exhibited diminished alpha-band FC as compared to HC. Furthermore, lower alpha-band FC between the medial temporal cortex - and the posterior cingulate cortex/precuneus was correlated with poorer memory performance.

Conclusions

Aberrant DMN connectivity, particularly in the alpha frequency range, might be a neural correlate of episodic memory impairment.

Significance

Our results inform the potential development of brain stimulation in managing memory impairments in aMCI.

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与失忆性 MCI 患者记忆功能障碍有关的默认模式网络中的α振荡断裂

目的在失忆性轻度认知障碍（aMCI）患者中发现了外显记忆功能障碍和默认模式网络（DMN）功能连接（FC）的改变。然而，以往的研究在探究默认模式网络内的某些振荡时受到了限制。本研究采用静息态FC对DMN内的各种振荡进行测量，以全面研究AMCI患者的FC及其与外显记忆表现的关系：我们招募了26名健康对照组（HC）和30名aMCI患者进行静息态脑磁图记录。我们比较了这两组患者的频谱功率、各频段的峰值频率值以及 DMN 内的 FC 值。我们还研究了FC值与记忆表现的关联：结果：在区域节点中，没有观察到组间频谱功率和峰值频率值的明显差异。与 HC 相比，aMCI 患者的 alpha 波段 FC 值降低。此外，颞叶内侧皮层与扣带后皮层/楔回之间较低的α波段FC与较差的记忆表现相关：结论：DMN连接性异常，尤其是α频率范围内的连接性异常，可能是外显记忆障碍的神经相关因素：重要意义：我们的研究结果为开发脑刺激疗法治疗 aMCI 患者记忆障碍提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.