{"title":"A microglial compliment: controlling neuronal function from within","authors":"Dilara Hasavci, Thomas Blank","doi":"10.1038/s41392-024-01989-9","DOIUrl":null,"url":null,"abstract":"<p>A recent study published in <i>Cell</i> revealed that in the aging brain, the microglia-derived complement component C1q is internalized into neurons through endocytosis, integrates into ribonucleoprotein (RNP) complexes where it inhibits neuronal protein synthesis and alters the protein content. These findings demonstrate an unexpected intracellular function of C1q in neurons with significant implications for understanding age-related changes in brain function and potentially neurodegenerative diseases.<sup>1</sup></p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":null,"pages":null},"PeriodicalIF":40.8000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-01989-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A recent study published in Cell revealed that in the aging brain, the microglia-derived complement component C1q is internalized into neurons through endocytosis, integrates into ribonucleoprotein (RNP) complexes where it inhibits neuronal protein synthesis and alters the protein content. These findings demonstrate an unexpected intracellular function of C1q in neurons with significant implications for understanding age-related changes in brain function and potentially neurodegenerative diseases.1
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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