Bone augmentation using bioresorbable mesh domes containing bone graft granules

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-10-07 DOI:10.1007/s10856-024-06833-8
Toshiki Yanagisawa, Koichiro Hayashi, Kunio Ishikawa
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Abstract

Bone graft granules are valuable tools for ridge area bone grafting owing to their ease of manipulation and interconnected porous structure. Guided bone regeneration (GBR) using barrier membranes is commonly used for alveolar ridge augmentation; however, the surgical procedures are technically complicated. In this study, we fabricated bioresorbable mesh domes (BMDs) using two types of Vicryl mesh (woven and knitted types) containing carbonate apatite granules. BMD samples were prepared in three groups: upper sides made from the woven type (UW) and lower sides made from the woven type (LW) (the UW/LW group), upper sides made from the woven type (UW) and lower sides made from the knitted type (LK) (the UW/LK group), and upper sides made from the knitted type (UK) and lower sides made from the knitted type (LK) (the UK/LK group). The samples were subsequently implanted into rabbit calvaria, and radiomorphometric and histological analyses were conducted. The UK/LK group exhibited enhanced appositional bone formation because the knitted mesh on the skin side prevented the infiltration of a substantial amount of fibrous tissue. This increase in bone formation could be attributed to the interaction between granules and osteoprogenitors that pass through the mesh from the host bone. Conversely, the UW/LW and UW/LK groups presented limited appositional bone formation. Compared with knitted mesh, woven mesh might tend to be absorbed over a short span, allowing fibrous tissue invasion and inhibiting new bone formation. Additionally, BMDs could retain granules in a targeted location and avoid displacement of the granules to unintended locations.

Graphical Abstract

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使用含有骨移植颗粒的生物可吸收网状穹顶进行骨增量。
骨移植颗粒因其易于操作和相互连接的多孔结构而成为牙脊区骨移植的重要工具。使用屏障膜进行引导骨再生(GBR)通常用于牙槽嵴增量,但手术过程技术复杂。在这项研究中,我们使用两种含有碳酸盐磷灰石颗粒的 Vicryl 网(编织型和针织型)制作了生物可吸收网状穹顶(BMD)。制备的 BMD 样品分为三组:上侧由编织型(UW)制成,下侧由编织型(LW)制成(UW/LW 组);上侧由编织型(UW)制成,下侧由针织型(LK)制成(UW/LK 组);上侧由针织型(UK)制成,下侧由针织型(LK)制成(UK/LK 组)。随后将样品植入兔子的小腿,并进行放射形态计量学和组织学分析。UK/LK组显示出更强的附着骨形成能力,这是因为皮肤一侧的编织网阻止了大量纤维组织的渗入。骨形成的增加可归因于颗粒与从宿主骨穿过网眼的造骨细胞之间的相互作用。相反,UW/LW 组和 UW/LK 组的附着骨形成有限。与针织网相比,编织网可能倾向于在短时间内被吸收,从而允许纤维组织侵入并抑制新骨形成。此外,BMD 可以将颗粒保留在目标位置,避免颗粒移位到非预期位置。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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