Change in Nfkb/Nrf2/Bax Levels by High Monomeric Polyphenols Berries Extract (HMPBE) in Acute and Chronic Secondary Brain Damage.

IF 2.5 Q3 CELL BIOLOGY Cellular Physiology and Biochemistry Pub Date : 2024-10-06 DOI:10.33594/000000731

Sergio Modafferi, Francesco Molinari, Livia Interdonato, Roberta Fusco, Daniela Impellizzeri, Rosalba Siracusa, Ramona D'Amico, Ali S Abdelhameed, Uwe Wenzel, Ursula Jacobs, Tilman Fritsch, Naomi Osakabe, Salvatore Cuzzocrea, Vittorio Calabrese, Rosanna Di Paola, Marika Cordaro

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Abstract

Background/aims: High Monomeric Polyphenols Berries Extract (HMPBE) is a formula highly rich in polyphenols clinically proven to enhance learning and memory. It is currently used to enhances cognitive performance including accuracy, working memory and concentration.

Methods: Here, we investigated for the first time the beneficial effects of HMPBE in a mouse model of acute and chronic traumatic brain injury (TBI).

Results: HMPBE, at the dose of 15 mg/kg was able to reduce histological alteration as well as inflammation and lipid peroxidation. HMPBE ameliorate TBI by improving Nrf-2 pathway, reducing Nf-kb nuclear translocation and apoptosis, and ameliorating behavioral alteration such as anxiety and depression. Moreover, in the chronic model of TBI, HMPBE administration restored the decline of Tyrosine Hydroxylase (TH) and dopamine transporter (DAT) and the accumulation of a-synuclein into the midbrain region. This finding correlates the beneficial effect of HMPBE administration with the onset of parkinsonism related to traumatic brain damage.

Conclusion: The data may open a window for developing new support strategies to limit the neuroinflammation event of acute and chronic TBI.

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高单体多酚浆果提取物（HMPBE）对急性和慢性继发性脑损伤中 Nfkb/Nrf2/Bax 水平的影响。

背景/目的：高单体多酚浆果提取物（HMPBE）是一种富含多酚的配方，临床证明可增强学习和记忆能力。方法：在此，我们首次研究了高单体多酚浆果提取物对急性和慢性创伤性脑损伤（TBI）小鼠模型的有益影响：结果：剂量为15毫克/千克的羟丙基丁酸能够减轻组织学改变，并减少炎症和脂质过氧化反应。通过改善 Nrf-2 通路、减少 Nf-kb 核转位和细胞凋亡，以及改善焦虑和抑郁等行为改变，HMPBE 可改善创伤性脑损伤。此外，在慢性创伤性脑损伤模型中，服用 HMPBE 可抑制酪氨酸羟化酶（TH）和多巴胺转运体（DAT）的下降以及 a-突触核蛋白在中脑区域的聚集。这一发现将HMPBE的有益作用与创伤性脑损伤导致的帕金森病的发生联系起来：这些数据为开发新的支持策略以限制急性和慢性创伤性脑损伤的神经炎症事件打开了一扇窗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Physiology and Biochemistry 生物-生理学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.