Intensity-dependence of auditory-evoked potentials might present an early surrogate marker for post-stroke depression

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-09-19 DOI:10.1016/j.clinph.2024.09.014

Nico Meißner-Bendzko , Gunnar Waterstraat , Gabriel Curio , Andrea Rocco , Christina Hofmann-Shen

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Abstract

Objective

Post-stroke depression (PSD) is a common stroke complication, associated with severe physical and cognitive impairment. Low central serotonergic tone, associated with depression, inversely correlates with the intensity-dependence of auditory-evoked potentials (IDAP). Aim of this study was to investigate IDAP’s usability as early surrogate marker for PSD development by assessing the correlation between IDAP early after stroke and the occurrence of PSD from 4 weeks after stroke.

Methods

We assessed auditory-evoked potentials (AEP) and depressive symptoms using the Montgomery-Åsberg Depression Rating Scale (MADRS) at day 1 – 3 and > 30 after stroke onset. IDAP was calculated as the linear slope of the N1-P2 amplitude/stimulus intensity function (ASF).

Results

37 patients completed the study. We diagnosed 7 patients with PSD, defined as MADRS-score

\geq

7 at follow-up. The PSD group showed significantly steeper ASF slopes at admission compared with the non-depressed group (p = 0.007). We also found a positive correlation between ASF slopes on first and MADRS-scores on last measurement point for all stroke patients as a group (p = 0.007).

Conclusions

The study findings support the hypothesis that IDAP can predict the development of depressive symptoms following stroke and may therefore serve as an early surrogate marker for PSD.

Significance

This is the first longitudinal study to assess the relationship between IDAP and PSD.

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听觉诱发电位的强度依赖性可能是卒中后抑郁的早期替代标记。

目的：脑卒中后抑郁（PSD）是一种常见的脑卒中并发症，与严重的身体和认知障碍有关。与抑郁症相关的中枢血清素能张力低与听觉诱发电位（IDAP）的强度依赖性成反比。本研究旨在通过评估脑卒中后早期听觉诱发电位与脑卒中后 4 周内 PSD 发生之间的相关性，研究听觉诱发电位作为 PSD 早期替代标志物的可用性：方法：我们在中风发生后第 1-3 天和大于 30 天使用蒙哥马利-阿斯伯格抑郁量表（MADRS）评估听觉诱发电位（AEP）和抑郁症状。IDAP 以 N1-P2 振幅/刺激强度函数 (ASF) 的线性斜率计算：37名患者完成了研究。我们诊断出 7 名患者患有 PSD，其定义是随访时 MADRS 评分≥ 7。与非抑郁组相比，PSD 组患者入院时的 ASF 斜率明显更陡（p = 0.007）。我们还发现，所有中风患者作为一个群体，首次测量时的 ASF 斜率与最后一次测量时的 MADRS 评分呈正相关（p = 0.007）：研究结果支持以下假设：IDAP 可预测卒中后抑郁症状的发展，因此可作为 PSD 的早期替代标记物：这是首个评估 IDAP 与 PSD 关系的纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.