Salivary Antimicrobial Peptide in Patients With Dementia Before and After Clinical Oral Rehabilitation Programme: A Randomised Controlled Trial.

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of oral rehabilitation Pub Date : 2024-10-06 DOI:10.1111/joor.13867

Ming-An Chen, Yuan-Han Yang, Ching-Kuan Liu, Koichiro Matsuo, Chih-Cheng Hsu, Ying-Chu Lin, Hsiao-Ling Huang

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Abstract

Background: Emerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis.

Objective: We investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health-related quality of life (OHRQoL).

Methods: Eligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self-care practices. Saliva samples and OHRQoL data were collected at baseline and follow-up visits. Generalised estimating equation models were used to analyse the changes over time.

Results: At the 3-month follow-up, EG showed significantly lower histatin 5 (HTN-5) levels (β = -0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (β = 0.89; ES = 0.89) and OHRQoL (β = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (β = 4.03), HTN-5 level (β = -0.78) and beta-defensin 2 level (BD-2) (β = -0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05).

Conclusions: Our clinical oral rehabilitation programme reduced the level of salivary HTN-5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN-5 level and BD-2 level were associated with improvements in patients' OHRQoL.

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临床口腔康复计划前后痴呆症患者的唾液抗菌肽：随机对照试验

背景：新的证据表明唾液代谢物的变化与神经退行性痴呆症之间存在联系，其中抗菌肽（AMPs）与痴呆症的发病机制有关：我们研究了为痴呆症患者量身定制的临床口腔康复计划对唾液流量、AMP 水平和口腔健康相关生活质量（OHRQoL）的影响：符合条件的患者被随机分配到实验组（EG；n = 28）或对照组（CG；n = 27）。两组患者均收到一份口腔健康宣传单。此外，实验组还接受了口腔护理干预，包括口腔肌肉锻炼和口腔自我护理方法的个人课程。在基线和随访时收集唾液样本和 OHRQoL 数据。采用广义估计方程模型分析随时间的变化：结果：在 3 个月的随访中，EG 的组蛋白 5 (HTN-5) 水平（β = -0.08；效应大小 [ES] = 0.72）明显低于 CG。6 个月时，与 CG 相比，EG 的唾液流速（β = 0.89；ES = 0.89）和 OHRQoL（β = 6.99；ES = 1.31）均有所改善。3 个月时唾液流速（β = 4.03）、HTN-5 水平（β = -0.78）和 beta-defensin 2 水平（BD-2）（β = -0.91）的变化预示着 6 个月时 OHRQoL 的改善（所有 p 均为结论：我们的临床口腔康复计划降低了痴呆症患者唾液 HTN-5 的水平，增加了唾液流量，提高了他们的 OHRQoL。此外，唾液流量、HTN-5 水平和 BD-2 水平的变化与患者 OHRQoL 的改善相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.