Beyond borders: the choroid plexus-immune communication during neuroinflammation

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-10-08 DOI:10.1038/s41392-024-01997-9
Anaelle Aurelie Dumas, Adrià Dalmau Gasull, Marco Prinz
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Abstract

In their paper published in Cell,1 Xu et al. leveraged single-cell sequencing and cell lineage tracing tools combined with two-photon live imaging to characterise the spatiotemporal immune recruitment and infiltration to the choroid plexus (ChP). They provide seminal insights into the communication between specialised ChP epithelial and macrophage populations, which coordinate the stepwise response to inflammation and its resolution.

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超越边界:神经炎症期间脉络丛与免疫的交流
在发表于《细胞》1 的论文中,Xu 等人利用单细胞测序和细胞系追踪工具,结合双光子实时成像技术,描述了脉络丛(ChP)的时空免疫招募和浸润特征。他们对专门的脉络丛上皮细胞和巨噬细胞群之间的交流提供了开创性的见解,这些细胞群协调了对炎症的逐步反应和解决。
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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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