Recent trends in the elucidation of complex triterpene biosynthetic pathways in horticultural trees

IF 8.7 1区农林科学 Q1 Agricultural and Biological Sciences Horticulture Research Pub Date : 2024-10-08 DOI:10.1093/hr/uhae254

Sandeep Dinday

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Abstract

Triterpene (C30 isoprene compounds) represents the most structurally diverse class of natural products and has been extensively exploited in the food, medicine and industrial sectors. Decades of research on medicinal triterpene biosynthetic pathways have revealed their roles in stress tolerance and shaping microbiota. However, the biological function and mechanism of triterpenes are not fully identified. Even this scientific window narrows down for horticultural trees. The lack of knowledge and a scalable production system limits the discovery of triterpene pathways. Recent synthetic biology research revealed several important biosynthetic pathways that define their roles and address many societal sustainability challenges. Here, I review the chemical diversity and biosynthetic enzymes involved in triterpene biosynthesis of horticultural trees. This review also outlines the integrated Design-Build-Test-Learn (DBTL) pipelines for the discovery, characterization and optimization of triterpene biosynthetic pathways. Further, these DBTL components share many fundamental and technical difficulties, highlighting opportunities for interdisciplinary collaboration between researchers worldwide. This advancement opens up unprecedented opportunities for the bioengineering of triterpene compounds towards development and scaleup processes.

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阐明园艺树复杂三萜生物合成途径的最新趋势

三萜（C30 异戊二烯化合物）是结构最多样化的一类天然产品，已在食品、医药和工业领域得到广泛开发。数十年来对药用三萜生物合成途径的研究揭示了它们在应激耐受性和塑造微生物群方面的作用。然而，三萜类化合物的生物功能和机制尚未完全确定。对于园艺树木来说，这一科学窗口也在缩小。知识和可扩展生产系统的缺乏限制了三萜途径的发现。最近的合成生物学研究揭示了几种重要的生物合成途径，确定了它们的作用，并解决了许多社会可持续发展的挑战。在此，我回顾了园艺树木三萜生物合成所涉及的化学多样性和生物合成酶。这篇综述还概述了用于发现、表征和优化三萜生物合成途径的集成设计-构建-测试-学习（DBTL）管道。此外，这些 DBTL 组成部分共享许多基础和技术难题，凸显了全球研究人员之间的跨学科合作机会。这一进步为三萜化合物的生物工程开发和放大过程带来了前所未有的机遇。

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来源期刊

Horticulture Research Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

11.20

自引率

6.90%

发文量

367

审稿时长

20 weeks

期刊介绍： Horticulture Research, an open access journal affiliated with Nanjing Agricultural University, has achieved the prestigious ranking of number one in the Horticulture category of the Journal Citation Reports ™ from Clarivate, 2022. As a leading publication in the field, the journal is dedicated to disseminating original research articles, comprehensive reviews, insightful perspectives, thought-provoking comments, and valuable correspondence articles and letters to the editor. Its scope encompasses all vital aspects of horticultural plants and disciplines, such as biotechnology, breeding, cellular and molecular biology, evolution, genetics, inter-species interactions, physiology, and the origination and domestication of crops.