Recent advances in surface plasmon resonance for the detection of ovarian cancer biomarkers: a thorough review

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-10-09 DOI:10.1007/s00604-024-06740-3

Shahnam Valizadeh Shahbazlou, Somayeh Vandghanooni, Bahareh Dabirmanesh, Morteza Eskandani, Sadegh Hasannia

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Abstract

Early detection of ovarian cancer (OC) is crucial for effective management and treatment, as well as reducing mortality rates. However, the current diagnostic methods for OC are time-consuming and have low accuracy. Surface plasmon resonance (SPR) biosensors offer a promising alternative to conventional techniques, as they enable rapid and less invasive screening of various circulating indicators. These biosensors are widely used for biomolecular interaction analysis and detecting tumor markers, and they are currently being investigated as a rapid diagnostic tool for early-stage cancer detection. Our main focus is on the fundamental concepts and performance characteristics of SPR biosensors. We also discuss the latest advancements in SPR biosensors that enhance their sensitivity and enable high-throughput quantification of OC biomarkers, including CA125, HE4, CEA, and CA19-9. Finally, we address the future challenges that need to be overcome to advance SPR biosensors from research to clinical applications. The ultimate goal is to facilitate the translation of SPR biosensors into routine clinical practice for the early detection and management of OC.

Graphical Abstract

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表面等离子体共振用于检测卵巢癌生物标记物的最新进展：全面回顾。

卵巢癌（OC）的早期检测对于有效管理和治疗以及降低死亡率至关重要。然而，目前的卵巢癌诊断方法耗时长、准确率低。表面等离子体共振（SPR）生物传感器能够快速、低侵入性地筛查各种循环指标，是传统技术的一种有前途的替代方法。这些生物传感器被广泛用于生物分子相互作用分析和肿瘤标志物检测，目前正被研究用作早期癌症检测的快速诊断工具。我们的主要重点是 SPR 生物传感器的基本概念和性能特点。我们还讨论了 SPR 生物传感器的最新进展，这些进展提高了传感器的灵敏度，实现了 OC 生物标记物（包括 CA125、HE4、CEA 和 CA19-9）的高通量定量。最后，我们探讨了未来需要克服的挑战，以推动 SPR 生物传感器从研究走向临床应用。我们的最终目标是促进 SPR 生物传感器转化为常规临床实践，用于 OC 的早期检测和管理。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.