Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine.

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biopolymers Pub Date : 2024-10-09 DOI:10.1002/bip.23631

Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri

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Abstract

In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate-succinic acid-polyethylene glycol 200 (HEMA-Suc-PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2 g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA-Suc-PEG and 0.2 g of PEGDA has the potential to be used in the cardiovascular system.

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开发 HEMA-琥珀酸-PEG 生物基单体，用于再生医学中的高性能水凝胶。

近年来，水凝胶在组织修复、康复和药物输送的再生医学中占据了特殊地位。要用于再生医学，水凝胶必须具有理想的物理、化学和生物特性。本研究合成并鉴定了一种基于甲基丙烯酸羟乙酯-丁二酸-聚乙二醇 200（HEMA-Suc-PEG）的新型生物单体。然后，使用合成的单体和不同比例的聚乙二醇二丙烯酸酯（PEGDA）作为交联剂，通过热固化和紫外固化方法合成了生物相容性水凝胶。对水凝胶的机械、物理、化学和生物特性以及心血管系统的重要组成部分内皮细胞的行为进行了评估。结果表明，用 0.2 克 PEGDA（紫外线固化）合成的水凝胶具有理想的机械和物理特性。生物测试表明，这些水凝胶不仅对细胞无毒，而且还能增强细胞粘附性。因此，含有合成单体 HEMA-Suc-PEG 和 0.2 克 PEGDA 的水凝胶有望用于心血管系统。

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来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.