Development of biocatalysts for high-value-added compounds.

Abstract

High-value-added compounds, such as monoterpenoids, are an important industrial targets because they are an essential group of compounds for pharmaceutical and industrial applications. Meanwhile, the depletion of natural resources and climate change demands sustainable production methods. In recent years, biocatalysis, which allows microbial bioproduction by regio- and stereo-selective reaction under mild conditions, has been attracted researchers' attention as a possible alternative to conventional methods. In this mini-review, we focus on the identification of biotransformation pathways in the non-model microorganism Acinetobacter sp. Tol 5 using geraniol, a representative monoterpenoid, and on the construction of an unconventional bioproduction method for high-value-added monoterpenoid (E)-geranic acid, which has great potential for industrial applications. This method offers a more environmentally friendly approach and insights contribute to optimizing biotransformation and bioproduction strategies for high-value-added compounds.