Mechanisms of ferroptosis and targeted therapeutic approaches in urological malignancies.

IF 6.1 2区生物学 Q1 CELL BIOLOGY Cell Death Discovery Pub Date : 2024-10-09 DOI:10.1038/s41420-024-02195-w

Wenjie Ma, Xiaotian Jiang, Ruipeng Jia, Yang Li

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Abstract

The prevalence of urological malignancies remains a significant global health concern, particularly given the challenging prognosis for patients in advanced disease stages. Consequently, there is a pressing need to explore the molecular mechanisms that regulate the development of urological malignancies to discover novel breakthroughs in diagnosis and treatment. Ferroptosis, characterized by iron-ion-dependent lipid peroxidation, is a form of programmed cell death (PCD) distinct from apoptosis, autophagy, and necrosis. Notably, lipid, iron, and glutathione metabolism intricately regulate intracellular ferroptosis, playing essential roles in the progression of various neoplasms and drug resistance. In recent years, ferroptosis has been found to be closely related to urological malignancies. This paper provides an overview of the involvement of ferroptosis in the pathogenesis and progression of urological malignancies, elucidates the molecular mechanisms governing its regulation, and synthesizes recent breakthroughs in diagnosing and treating these malignancies. We aim to provide a new direction for the clinical treatment of urological malignancies.

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泌尿系统恶性肿瘤的铁中毒机制和靶向治疗方法。

泌尿系统恶性肿瘤的发病率仍然是全球关注的一个重大健康问题，特别是考虑到晚期患者的预后极具挑战性。因此，迫切需要探索调控泌尿系统恶性肿瘤发展的分子机制，以发现诊断和治疗方面的新突破。以铁离子依赖性脂质过氧化为特征的铁变态反应是一种程序性细胞死亡（PCD），有别于细胞凋亡、自噬和坏死。值得注意的是，脂质、铁和谷胱甘肽代谢错综复杂地调控着细胞内的铁变态反应，在各种肿瘤的进展和耐药性中发挥着至关重要的作用。近年来，人们发现高铁血症与泌尿系统恶性肿瘤密切相关。本文概述了泌尿系统恶性肿瘤的发病和进展过程中的铁蛋白沉积过程，阐明了其调控的分子机制，并总结了诊断和治疗这些恶性肿瘤的最新突破。我们旨在为泌尿系统恶性肿瘤的临床治疗提供一个新的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.