Osseointegration of Anodized vs. Sandblasted Implant Surfaces in a Guided Bone Regeneration Acute Dehiscence-Type Defect: An In Vivo Experimental Mandibular Minipig Model

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Oral Implants Research Pub Date : 2024-10-10 DOI:10.1111/clr.14369

Shakeel Shahdad, Simon Rawlinson, Nahal Razaghi, Anuya Patankar, Mital Patel, Mario Roccuzzo, Thomas Gill

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Abstract

Objectives

This controlled preclinical study analyzed the effect of implant surface characteristics on osseointegration and crestal bone formation in a grafted dehiscence defect minipig model.

Material and Methods

A standardized 3 mm × 3 mm acute-type buccal dehiscence minipig model grafted with deproteinized bovine bone mineral and covered with a porcine collagen membrane after 2 and 8 weeks of healing was utilized. Crestal bone formation was analyzed histologically and histomorphometrically to compare three implant groups: (1) a novel, commercially available, gradient anodized (NGA) implant, to two custom-made geometric replicas of implant “1,” (2) a superhydrophilic micro-rough large-grit sandblasted and acid-etched surface, and (3) a relatively hydrophobic micro-rough large-grit sandblasted and acid-etched surface.

Results

At 2 and 8 weeks, there was no difference between the amount and height of newly formed bone (NBH, new bone height; BATA, bone area to total area) for any of the groups (p > 0.05). First bone-to-implant contact (fBIC) and vertical bone creep (VBC) at 2 and 8 weeks were significantly increased for Groups 2 and 3 compared to Group 1 (p < 0.05). At 8 weeks, osseointegration in the dehiscence (dehiscence bone-implant-contact; dBIC) was significantly higher for Groups 2 and 3 compared to Group 1 (p < 0.05).

Conclusions

The amount of newly formed bone (BATA) and NBH was not influenced by surface type. However, moderately rough surfaces demonstrated significantly superior levels of osseointegration (dBIC) and coronal bone apposition (fBIC) in the dehiscence defect compared to the NGA surface at 2 and 8 weeks.

Trial Registration

For this type of study, clinical trial registration is not required. This study was conducted at the Biomedical Department of Lund University (Lund, Sweden) and approved by the local Ethics Committee of the University (M-192-14)

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引导骨再生急性开裂型缺损中阳极氧化与喷砂种植体表面的骨结合：下颌骨迷你猪体内实验模型。

目的：本临床前对照研究分析了移植开裂缺损迷你猪模型中种植体表面特征对骨结合和骨嵴形成的影响：这项临床前对照研究分析了移植开裂缺损迷你猪模型中种植体表面特征对骨结合和骨嵴形成的影响：使用标准化的 3 mm × 3 mm 急性型颊裂微型猪模型，在模型愈合 2 周和 8 周后，用去蛋白牛骨矿物质进行移植，并覆盖猪胶原膜。通过组织学和组织形态计量学方法分析嵴骨形成情况，比较三组种植体：(1) 新型、市售、梯度阳极氧化（NGA）种植体和两个定制的种植体 "1 "几何复型；(2) 超亲水性微粗糙大颗粒喷砂和酸蚀表面；(3) 相对疏水性微粗糙大颗粒喷砂和酸蚀表面：2周和8周时，各组新形成骨的数量和高度（NBH，新骨高度；BATA，骨面积与总面积之比）均无差异（P > 0.05）。与第 1 组相比，第 2 组和第 3 组在 2 周和 8 周时的首次骨与种植体接触（fBIC）和垂直骨蠕变（VBC）显著增加（p 结论：第 2 组和第 3 组在 2 周和 8 周时的首次骨与种植体接触（fBIC）和垂直骨蠕变（VBC）显著增加（p新形成骨量 (BATA) 和 NBH 不受表面类型的影响。然而，在 2 周和 8 周时，与 NGA 表面相比，中等粗糙度表面在开裂缺损处的骨结合（dBIC）和冠状骨附着（fBIC）水平明显更高：此类研究无需进行临床试验注册。本研究在隆德大学（瑞典隆德）生物医学系进行，并获得了该大学当地伦理委员会的批准（M-192-14）。

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.