COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals.

IF 1.3 4区医学 Q4 PHYSIOLOGY Clinical Physiology and Functional Imaging Pub Date : 2024-10-08 DOI:10.1111/cpf.12909

Mushidur Rahman, Sophie L Russell, Nduka C Okwose, Gordon McGregor, Helen Maddock, Prithwish Banerjee, Djordje G Jakovljevic

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Abstract

Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in heathy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals.

Methods: A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise.

Results: There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012).

Conclusion: Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.

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COVID-19 与健康中老年人的心脏结构和功能重塑有关。

背景：2019年冠状病毒病（COVID-19）被宣布为2019年全球大流行病。目前仍不确定COVID-19对健康人心脏的影响程度。评估 COVID-19 对中老年人心脏结构和功能的影响：一项单中心前瞻性观察研究共招募了 124 名参与者（其中 84 人有 COVID-19 病史 [COVID-19 组]，40 人无 COVID-19 病史 [非 COVID 组]）。所有参与者都接受了斑点追踪超声心动图检查，以评估静息状态和运动高峰期的心脏结构和功能：结果：COVID-19 组和非 COVID-19 组的左心室和右心室舒张功能没有差异（P ≥ 0.05）。COVID-19 组参与者的左心室质量（130 ± 39.8 vs. 113 ± 27.2 g，p = 0.008）和相对室壁厚度（0.38 ± 0.07 vs. 0.36 ± 0.13，p = 0.049）较高。COVID-19 组的左心室整体纵向应变在静息和运动峰值时均有所降低（静息：18.3 ± 2.01 vs 0.36 ± 0.13，p = 0.049）：18.3 ± 2.01 vs. 19.3 ± 1.53%，p = 0.004；运动峰值：19.1 ± 2.20 vs. 21.0 ± 1.58%，p ≤ 0.001）。然而，各组间静息左心室射血分数（58 ± 2.89 vs. 59 ± 2.51%，p = 0.565）无差异。COVID-19组的右心室射血分数面积变化减少（p = 0.012）：结论：在有 COVID-19 病史的中老年健康人群中观察到心脏结构和功能重塑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.