Clinical Implications of the Molecular and Genomic Landscape of Upper Tract Urothelial Carcinoma.

IF 2.5 2区医学 Q2 UROLOGY & NEPHROLOGY Current Urology Reports Pub Date : 2024-10-08 DOI:10.1007/s11934-024-01245-1

Salvador Jaime-Casas, Abhishek Tripathi, Sumanta K Pal, Wesley Yip

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Abstract

Purpose of review: Upper tract urothelial carcinoma (UTUC) is an aggressive entity with treatment strategies mirroring bladder cancer. Genomic and molecular profiling allows for a better characterization of this disease and allows for patient-tailored approaches. We aim to describe the genomic and molecular implications of this disease.

Recent findings: Technological advances have the potential for early diagnosis and precise molecular analysis in patients with UTUC. Genomic profile clustering, specific mRNA signatures, and pathway-specific protein abundance tools have oncologic and clinical implications. We describe their utility in the context of this disease. In the era of precision medicine, designing clinical trials that explore the diagnostic and prognostic implications of biomolecular signatures in the context of UTUC is of utmost importance. Promising advances in this arena provide tools for physicians to avoid overtreatment in this patient population.

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上尿路上皮癌的分子和基因组图谱对临床的影响

综述目的：上尿路上皮癌（UTUC）是一种侵袭性肿瘤，其治疗策略与膀胱癌类似。基因组和分子图谱分析能更好地描述这种疾病的特征，并能采取适合患者的治疗方法。我们旨在描述这种疾病的基因组和分子影响：技术进步为UTUC患者的早期诊断和精确分子分析提供了可能。基因组图谱聚类、特定mRNA特征和通路特异性蛋白质丰度工具对肿瘤学和临床具有重要意义。我们将介绍这些工具在该疾病中的应用。在精准医疗时代，设计临床试验以探索生物分子特征对UTUC诊断和预后的影响至关重要。在这一领域取得的可喜进展为医生提供了避免对这一患者群体过度治疗的工具。

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来源期刊

Current Urology Reports UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

3.80%

发文量

期刊介绍： This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.