Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.

IF 9.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL EClinicalMedicine Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI:10.1016/j.eclinm.2024.102848
Xiao-Dong Zhou, Qin-Fen Chen, Wah Yang, Mauricio Zuluaga, Giovanni Targher, Christopher D Byrne, Luca Valenti, Fei Luo, Christos S Katsouras, Omar Thaher, Anoop Misra, Karim Ataya, Rodolfo J Oviedo, Alice Pik-Shan Kong, Khalid Alswat, Amedeo Lonardo, Yu Jun Wong, Adam Abu-Abeid, Hazem Al Momani, Arshad Ali, Gabriel Alejandro Molina, Olivia Szepietowski, Nozim Adxamovich Jumaev, Mehmet Celal Kızılkaya, Octavio Viveiros, Carlos Jesus Toro-Huamanchumo, Kenneth Yuh Yen Kok, Oral Ospanov, Syed Imran Abbas, Andrew Gerard Robertson, Yasser Fouad, Christos S Mantzoros, Huijie Zhang, Nahum Méndez-Sánchez, Silvia Sookoian, Wah-Kheong Chan, Sombat Treeprasertsuk, Leon Adams, Ponsiano Ocama, John D Ryan, Nilanka Perera, Ala I Sharara, Said A Al-Busafi, Christopher Kenneth Opio, Manuel Garcia, Michelle Ching Lim-Loo, Elena Ruiz-Úcar, Arun Prasad, Anna Casajoana, Tamer N Abdelbaki, Ming-Hua Zheng
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引用次数: 0

Abstract

Background: Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood.

Methods: We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m2 for individuals aged ≥20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, sex, year, geographical location, and SDI.

Findings: From 1990 to 2021, the global deaths and DALYs attributable to high BMI increased more than 2.5-fold for females and males. However, the age-standardized death rates remained stable for females and increased by 15.0% for males. Similarly, the age-standardized DALY rates increased by 21.7% for females and 31.2% for males. In 2021, the six leading causes of high BMI-attributable DALYs were diabetes mellitus, ischemic heart disease, hypertensive heart disease, chronic kidney disease, low back pain and stroke. From 1990 to 2021, low-middle SDI countries exhibited the highest annual percentage changes in age-standardized DALY rates, whereas high SDI countries showed the lowest.

Interpretation: The worldwide health burden attributable to high BMI has grown significantly between 1990 and 2021. The increasing global rates of high BMI and the associated disease burden highlight the urgent need for regular surveillance and monitoring of BMI.

Funding: National Natural Science Foundation of China and National Key R&D Program of China.

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高体重指数导致的疾病负担:2021 年全球疾病负担研究数据分析。
背景:肥胖症是一项重大的全球性健康挑战,对临床具有重要影响。尽管其重要性已得到公认,但人们对高体重指数(BMI)导致的全球疾病负担仍然知之甚少:方法:我们采用 2021 年全球疾病负担研究(GBD)的方法和分析方法,系统分析了高体重指数导致的全球死亡人数和残疾调整生命年数(DALYs)。高体重指数被定义为年龄≥20 岁的个体体重指数超过 25 kg/m2。社会人口指数(SDI)作为一项综合指标,用于评估不同地区的社会经济发展水平。分组分析考虑了年龄、性别、年份、地理位置和 SDI:从 1990 年到 2021 年,全球女性和男性因高体重指数导致的死亡人数和残疾调整寿命年数增加了 2.5 倍以上。然而,女性的年龄标准化死亡率保持稳定,男性则增加了 15.0%。同样,女性的年龄标准化残疾调整寿命年数增加了 21.7%,男性增加了 31.2%。2021 年,造成高体重指数可归因于残疾调整寿命年数的六大主要原因是糖尿病、缺血性心脏病、高血压性心脏病、慢性肾病、腰痛和中风。从 1990 年到 2021 年,中低 SDI 国家的年龄标准化残疾调整寿命年率的年百分比变化最大,而高 SDI 国家的变化最小:从 1990 年到 2021 年,高体重指数造成的全球健康负担显著增加。全球高体重指数发病率和相关疾病负担的增加凸显了对体重指数进行定期监测和监控的迫切需要:国家自然科学基金和国家重点研发计划。
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来源期刊
EClinicalMedicine
EClinicalMedicine Medicine-Medicine (all)
CiteScore
18.90
自引率
1.30%
发文量
506
审稿时长
22 days
期刊介绍: eClinicalMedicine is a gold open-access clinical journal designed to support frontline health professionals in addressing the complex and rapid health transitions affecting societies globally. The journal aims to assist practitioners in overcoming healthcare challenges across diverse communities, spanning diagnosis, treatment, prevention, and health promotion. Integrating disciplines from various specialties and life stages, it seeks to enhance health systems as fundamental institutions within societies. With a forward-thinking approach, eClinicalMedicine aims to redefine the future of healthcare.
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