A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell.

IF 3.7 2区生物学 Q1 DEVELOPMENTAL BIOLOGY Development Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI:10.1242/dev.203019

Theadora Tolkin, Julia Burnett, E Jane Albert Hubbard

引用次数: 0

Abstract

The morphology of cells in vivo can arise from a variety of mechanisms. In the Caenorhabditis elegans hermaphrodite gonad, the distal tip cell (DTC) elaborates into a complex plexus over a relatively short developmental time period, but the mechanisms underlying this change in cell morphology are not well defined. We correlated the time of DTC elaboration with the L4-to-adult molt, but ruled out a relevant heterochronic pathway as a cue for DTC elaboration. Instead, we found that the timing of gonad elongation and aspects of underlying germline flux influence DTC elaboration. We propose a 'hitch and tow' aspect of organ-level dynamics that contributes to cellular morphogenesis, whereby germline flux drags the flexible DTC cell cortex away from its stationary cell body. More broadly, we speculate that this mechanism may contribute to cell shape changes in other contexts with implications for development and disease.

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器官水平动力学在秀丽隐杆线虫雌雄同体远端细胞形态发生中的作用

体内细胞的形态可由多种机制产生。在秀丽隐杆线虫雌雄同体性腺中，远端顶端细胞（DTC）在相对较短的发育时间内发育成复杂的丛状细胞，但细胞形态发生这种变化的机制尚未明确。我们将 DTC 的发育时间与 L4 到成体的蜕皮时间相关联，但排除了作为 DTC 发育线索的相关异时途径。相反，我们发现性腺伸长的时间和潜在种系通量的各个方面都会影响 DTC 的形成。我们提出了器官水平动态的 "搭拖 "机制，它有助于细胞形态发生，即生殖系通量将灵活的DTC细胞皮层拖离其固定的细胞体。更广泛地说，我们推测这种机制可能有助于其他情况下的细胞形态变化，从而对发育和疾病产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

期刊介绍： Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community. Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication. To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.