T7 Peptide-modified macrophage membrane-coated nanoplatform for enhanced glioma treatment

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2024-10-09 DOI:10.1016/j.ejpb.2024.114527

Xuanrong Sun , Dehui Xie , Zhao Lou , Yujie Zhou , Ming Li , Qingyong Li , Yue Cai

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Abstract

The efficient and secure delivery of intravenous chemotherapeutic agents across the blood–brain barrier (BBB) to the precise location of a brain tumor is a crucial element in glioma treatment. Herein, we introduce a biomimetic nanoplatform (T7-M-C/S) comprising a core made up of irinotecan hydrochloride (CPT11) and its bioactive metabolite, 7-Ethyl-10-hydroxycamptothecin (SN38), surrounded by a layer of T7-peptide-modified macrophage membrane. CPT11 spontaneously assembles with SN38 into stable and water-dispersible nanoparticles (C/S), greatly enhancing the water solubility of SN38. The integration of the modified peptide with the inherent proteins expressed by macrophage cells confers the nanoplatform with enhanced bioavailability and robust glioma-targeting abilities, ultimately resulting in superior therapeutic outcomes. These discoveries highlight a drug delivery system characterized by a high drug loading capacity, leveraging the macrophage membrane, and promising significant potential for glioma treatment.

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T7 肽修饰的巨噬细胞膜包被纳米平台用于增强胶质瘤治疗。

高效、安全地将静脉化疗药物通过血脑屏障（BBB）输送到脑肿瘤的精确位置是胶质瘤治疗的关键因素。在这里，我们介绍了一种生物仿生纳米平台（T7-M-C/S），它由盐酸伊立替康（CPT11）及其生物活性代谢物7-乙基-10-羟基喜树碱（SN38）组成的核心，周围是一层T7肽修饰的巨噬细胞膜。CPT11 自发地与 SN38 组装成稳定的水分散纳米颗粒（C/S），大大提高了 SN38 的水溶性。经过修饰的多肽与巨噬细胞表达的固有蛋白相结合，使纳米平台具有更高的生物利用度和强大的胶质瘤靶向能力，最终实现卓越的治疗效果。这些发现凸显了一种利用巨噬细胞膜、具有高载药量特点的给药系统，有望为胶质瘤治疗带来巨大潜力。

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来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.