Comprehensive in silico analysis of prognostic and immune infiltrates for FGFs in human ovarian cancer.

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY Journal of Ovarian Research Pub Date : 2024-10-09 DOI:10.1186/s13048-024-01496-z

Yu Wang, Haiyue Zhang, Yuanyuan Zhan, Zhuoran Li, Sujing Li, Shubin Guo

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Abstract

Background: Fibroblast growth factors (FGFs) are cell signaling proteins that perform multiple biological processes in many biological processes (cell development, repair, and metabolism). The dynamics of tumor cells, such as angiogenesis, transformation, and proliferation, have a significant impact on neoplasia and are modulated by FGFs. FGFs' expression and prognostic significance in ovarian cancer (OC), however, remain unclear.

Methods: Through a series of in silico analysis, we investigated the transcriptional, survival data, genetic variation, gene-gene interaction network, ferroptosis-related genes, and DNA methylation of FGFs in OC patients.

Results: We discovered that while FGF18 expression levels were higher in OC tissues than in normal OC tissues, FGF2/7/10/17/22 expression levels were lower in the former, and that FGF1/19 expression was related to the tumor stage in OC patients. According to the survival analysis, the clinical prognosis of individuals with OC was associated with the aberrant expression of FGFs. The function of FGFs and their neighboring genes was mainly connected to the cellular response to FGF stimulus. There was a negative correlation between FGF expression and various immune cell infiltration.

Conclusions: This study clarifies the relationship between FGFs and OC, which might provide new insights into the choice of prognostic biomarkers of OC patients.

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对人类卵巢癌 FGFs 的预后和免疫浸润进行全面的硅学分析。

背景：成纤维细胞生长因子（FGFs）是一种细胞信号蛋白，在许多生物过程（细胞发育、修复和新陈代谢）中执行多种生物学过程。肿瘤细胞的动态变化，如血管生成、转化和增殖，对肿瘤的发生有重要影响，并受 FGFs 的调节。然而，FGFs在卵巢癌（OC）中的表达和预后意义仍不清楚：方法：我们通过一系列的硅学分析，研究了卵巢癌患者中 FGFs 的转录、生存数据、遗传变异、基因-基因相互作用网络、铁突变相关基因以及 DNA 甲基化情况：结果：我们发现FGF18在OC组织中的表达水平高于正常OC组织，而FGF2/7/10/17/22在前者中的表达水平较低，且FGF1/19的表达与OC患者的肿瘤分期有关。根据生存分析，OC 患者的临床预后与 FGFs 的异常表达有关。FGFs及其邻近基因的功能主要与细胞对FGF刺激的反应有关。FGF表达与各种免疫细胞浸润呈负相关：本研究阐明了FGFs与OC之间的关系，为选择OC患者的预后生物标志物提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.