Outcomes after intranasal human milk therapy in preterm infants with intraventricular hemorrhage

IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-10-09 DOI:10.1038/s41372-024-02147-3
Alessia Gallipoli, Sharon Unger, Amr El Shahed, Chun-Po Steve Fan, Marisa Signorile, Diane Wilson, Rebecca Hoban
{"title":"Outcomes after intranasal human milk therapy in preterm infants with intraventricular hemorrhage","authors":"Alessia Gallipoli, Sharon Unger, Amr El Shahed, Chun-Po Steve Fan, Marisa Signorile, Diane Wilson, Rebecca Hoban","doi":"10.1038/s41372-024-02147-3","DOIUrl":null,"url":null,"abstract":"Intraventricular hemorrhage (IVH) is a common cause of brain injury in preterm infants. Fresh human milk (HM) contains stem cells (SCs) that could potentially be delivered via intranasal HM (IHM). In this IHM pilot study, we describe outcomes. Infants <33 weeks gestation with IVH were given IHM until maximum 28 days of age. Short-term neurologic outcomes and follow-up testing were compared to historic HM-fed infants. Longitudinal outcomes were plotted using linear mixed models. Weighted G-computation quantified treatment effects. Propensity score models calculated inverse probability weights for IVH grade, gestational age, and sex. 37 infants (35.1% grade 3-4 IVH) were compared to 191 historic controls (17.8% grade 3-4 IVH). Post-hemorrhagic ventricular dilatation was common (25.7% IHM patients). Most weighted outcomes, although not significant, favored IHM at 4-12 and 18 months corrected age. This phase 1 study suggests powered trials of IHM for brain injury are needed. clinicaltrials.gov identifier NCT04225286","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 2","pages":"202-207"},"PeriodicalIF":2.4000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41372-024-02147-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Intraventricular hemorrhage (IVH) is a common cause of brain injury in preterm infants. Fresh human milk (HM) contains stem cells (SCs) that could potentially be delivered via intranasal HM (IHM). In this IHM pilot study, we describe outcomes. Infants <33 weeks gestation with IVH were given IHM until maximum 28 days of age. Short-term neurologic outcomes and follow-up testing were compared to historic HM-fed infants. Longitudinal outcomes were plotted using linear mixed models. Weighted G-computation quantified treatment effects. Propensity score models calculated inverse probability weights for IVH grade, gestational age, and sex. 37 infants (35.1% grade 3-4 IVH) were compared to 191 historic controls (17.8% grade 3-4 IVH). Post-hemorrhagic ventricular dilatation was common (25.7% IHM patients). Most weighted outcomes, although not significant, favored IHM at 4-12 and 18 months corrected age. This phase 1 study suggests powered trials of IHM for brain injury are needed. clinicaltrials.gov identifier NCT04225286
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
早产儿脑室内出血鼻内人乳疗法后的疗效。
目的:脑室内出血(IVH)是早产儿脑损伤的常见原因。新鲜母乳(HM)中含有干细胞(SCs),可通过鼻内HM(IHM)输送。在这项IHM试点研究中,我们描述了研究结果:结果:37名婴儿(35.1%为3-4级IVH)与191名历史对照组(17.8%为3-4级IVH)进行了比较。出血后心室扩张很常见(25.7% 的 IHM 患者)。大多数加权结果虽然不显著,但在4-12个月和18个月矫正年龄时更倾向于IHM:这项 1 期研究表明,需要对治疗脑损伤的 IHM 进行有动力的试验。临床试验注册名称:clinicaltrials.gov 识别码 NCT04225286。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Perinatology
Journal of Perinatology 医学-妇产科学
CiteScore
5.40
自引率
6.90%
发文量
284
审稿时长
3-8 weeks
期刊介绍: The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
期刊最新文献
It's the little things. A framework and guidance for programs to care for infants 22-23 weeks' gestational age. Does ventilatory assistance before umbilical cord clamping reduce the risk of early death or intraventricular hemorrhage in extremely preterm infants? Electrical impedance tomography imaging of ventilation and perfusion in bronchopulmonary dysplasia. A prospective randomized pilot trial comparing weekly vs. biweekly Darbepoetin administration to preterm infants. Diagnostic evaluation to identify infection-attributable stillbirth.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1