Acne-related UVA-induced facial fluorescence: An exploratory study from physiological properties to tissue structure information

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of photochemistry and photobiology. B, Biology Pub Date : 2024-10-02 DOI:10.1016/j.jphotobiol.2024.113042
Xing Ren , Yanan Sun , Yuxin Zhang , Na Zhou , Yunong Wang , Lishuang Li , Xinyu Gao , Yuman Ma , Xianyu Li , Zhe Shu , Honghui He , Yi Wang
{"title":"Acne-related UVA-induced facial fluorescence: An exploratory study from physiological properties to tissue structure information","authors":"Xing Ren ,&nbsp;Yanan Sun ,&nbsp;Yuxin Zhang ,&nbsp;Na Zhou ,&nbsp;Yunong Wang ,&nbsp;Lishuang Li ,&nbsp;Xinyu Gao ,&nbsp;Yuman Ma ,&nbsp;Xianyu Li ,&nbsp;Zhe Shu ,&nbsp;Honghui He ,&nbsp;Yi Wang","doi":"10.1016/j.jphotobiol.2024.113042","DOIUrl":null,"url":null,"abstract":"<div><div>UVA-induced facial fluorescence (UVAF) is recognized as an objective measurement technique to quantify the severity of acne. However, notable inconsistencies in quantitative outcomes have been observed in various studies, possibly due to the fact that different colors of fluorescence represent different pathophysiological implications. This study investigated the pathophysiological importance of UVAF color differences and improved its reliability in assessing acne severity. MIDOO Smart Skin Imager was used to capture UVAF and analyze the correlation between fluorescence colors and acne lesions. Techniques such as two-photon excited fluorescence microscopy, scanning electron microscopy, western blot, and high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) were used to examine the biochemical composition and structure of comedonal plugs and follicular casts associated with different fluorescence colors. We found that green fluorescence correlates with non-inflammatory acne lesions (comedones), while orange-red fluorescence shows no correlation with either type of lesion. Green fluorescence is associated with higher levels of keratin, indicating keratinization, while orange-red fluorescence is associated with porphyrin from <em>S. epidermidis</em>. UVAF color differences - orange-red are from porphyrins and green from keratin. This distinction helps to understand the structural and physiological bases of facial fluorescence, with potential implications for clinical evaluations of acne.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of photochemistry and photobiology. B, Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1011134424002021","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

UVA-induced facial fluorescence (UVAF) is recognized as an objective measurement technique to quantify the severity of acne. However, notable inconsistencies in quantitative outcomes have been observed in various studies, possibly due to the fact that different colors of fluorescence represent different pathophysiological implications. This study investigated the pathophysiological importance of UVAF color differences and improved its reliability in assessing acne severity. MIDOO Smart Skin Imager was used to capture UVAF and analyze the correlation between fluorescence colors and acne lesions. Techniques such as two-photon excited fluorescence microscopy, scanning electron microscopy, western blot, and high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) were used to examine the biochemical composition and structure of comedonal plugs and follicular casts associated with different fluorescence colors. We found that green fluorescence correlates with non-inflammatory acne lesions (comedones), while orange-red fluorescence shows no correlation with either type of lesion. Green fluorescence is associated with higher levels of keratin, indicating keratinization, while orange-red fluorescence is associated with porphyrin from S. epidermidis. UVAF color differences - orange-red are from porphyrins and green from keratin. This distinction helps to understand the structural and physiological bases of facial fluorescence, with potential implications for clinical evaluations of acne.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
与痤疮相关的 UVA 引起的面部荧光:从生理特性到组织结构信息的探索性研究。
紫外线诱导面部荧光(UVAF)被认为是量化痤疮严重程度的一种客观测量技术。然而,在不同的研究中观察到的定量结果存在明显的不一致,这可能是由于不同颜色的荧光代表了不同的病理生理学含义。本研究探讨了 UVAF 颜色差异在病理生理学方面的重要性,并提高了其在评估痤疮严重程度方面的可靠性。MIDOO 智能皮肤成像仪用于捕捉 UVAF 并分析荧光颜色与痤疮皮损之间的相关性。双光子激发荧光显微镜、扫描电子显微镜、Western 印迹和高效液相色谱-质谱联用仪(HPLC-MS/MS)等技术被用来检测与不同荧光颜色相关的粉刺栓和毛囊铸型的生化组成和结构。我们发现,绿色荧光与非炎症性痤疮皮损(粉刺)相关,而橙红色荧光与这两种皮损均无相关性。绿色荧光与较高水平的角蛋白有关,表明角质化,而橙红色荧光则与表皮葡萄球菌产生的卟啉有关。UVAF 的颜色差异--橙红色来自卟啉,绿色来自角蛋白。这种区别有助于了解面部荧光的结构和生理基础,对痤疮的临床评估具有潜在的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
12.10
自引率
1.90%
发文量
161
审稿时长
37 days
期刊介绍: The Journal of Photochemistry and Photobiology B: Biology provides a forum for the publication of papers relating to the various aspects of photobiology, as well as a means for communication in this multidisciplinary field. The scope includes: - Bioluminescence - Chronobiology - DNA repair - Environmental photobiology - Nanotechnology in photobiology - Photocarcinogenesis - Photochemistry of biomolecules - Photodynamic therapy - Photomedicine - Photomorphogenesis - Photomovement - Photoreception - Photosensitization - Photosynthesis - Phototechnology - Spectroscopy of biological systems - UV and visible radiation effects and vision.
期刊最新文献
Light and phytochrome PHY control the production of edible fungus Flammulina filiformis by regulating the morphogenesis of fruiting bodies and l-lysine accumulation Liposomal chlorin e6-mediated photodynamic therapy induces cell pyroptosis and promotes anti-tumor immune effects in breast cancer A BODIPY derivative for PDT/PTT synergistic treatment of bacterial infections Enhanced anticancer efficacy of photodynamic therapy in combination with immunotherapy Synergistic effect of folic acid and hypericin administration to improve the efficacy of photodynamic therapy via folate receptors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1