Gingival Proliferative Verrucous Leukoplakia and Cancer: A Systematic Review With Meta-Analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-09 DOI:10.1111/odi.15142

Valentin Vergier, André Luís Porporatti, Sylvie Babajko, Ihsène Taihi

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Abstract

Objective: Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder. Forms that affect only one tissue are poorly studied, especially the exclusively gingival PVL (gPVL), which may have a more increased malignant transformation potential. The aim of the present study was to characterise the gPVL and its risk of malignant transformation to better raise awareness of this specific disorder.

Materials and methods: The systematic review was performed on PubMed, Scopus, Web of Science and Google Scholar. Only articles reporting primary studies, case reports and case series were included. The meta-analysis was performed for the cancer prevalence, proportion of smokers, age and sex ratio, recurrences of gPVL and mortality.

Results: A total of 1298 studies were assessed for eligibility by reading titles and abstracts. Fourteen original articles were included with a total of 58 patients. The malignant transformation rate of gPVL was 47.75%. The mortality was 5.84%. The mean follow-up duration before malignant transformation was 3 years.

Conclusion: gPVL seems to have a faster malignant transformation rate than the other forms of PVL. Finding anatomo-pathological or genetic markers could be a line of research to predict gPVL malignant transformation and improve its diagnosis and treatment.

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牙龈增生性疣状白斑与癌症：带 Meta 分析的系统性综述

目的：增殖性疣状白斑（PVL）是一种口腔潜在恶性疾病。目前对仅累及一种组织的增生性疣状白斑（PVL）研究较少，尤其是仅累及牙龈的增生性疣状白斑（gPVL），其恶变可能性可能更大。本研究旨在描述 gPVL 的特征及其恶变风险，以更好地提高人们对这一特殊疾病的认识：系统综述在 PubMed、Scopus、Web of Science 和 Google Scholar 上进行。仅纳入了报告主要研究、病例报告和系列病例的文章。对癌症发病率、吸烟者比例、年龄和性别比例、gPVL 复发率和死亡率进行了荟萃分析：通过阅读标题和摘要，共对 1298 项研究进行了资格评估。共收录了 14 篇原创文章，涉及 58 名患者。gPVL的恶性转化率为47.75%。死亡率为 5.84%。结论：与其他形式的 PVL 相比，gPVL 的恶性转化率似乎更快。结论：gPVL 的恶性转化率似乎比其他形式的 PVL 更快，寻找解剖病理学或遗传学标记可能是预测 gPVL 恶性转化并改善其诊断和治疗的一个研究方向。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.