Clinical and imaging correlates of hyperorality in syndromes associated with frontotemporal lobar degeneration.

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY Psychiatry and Clinical Neurosciences Pub Date : 2024-10-07 DOI:10.1111/pcn.13751
Daniele Altomare, Valeria Bracca, Enrico Premi, Anna Micheli, Maria Sofia Cotelli, Roberto Gasparotti, Antonella Alberici, Barbara Borroni
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Abstract

Aim: Empirical research investigating hyperorality in syndromes associated with frontotemporal lobar degeneration (FTLD) is limited. The present study aims to assess and describe hyperorality and its clinical and imaging correlates in patients with FTLD-associated syndromes.

Methods: This retrospective longitudinal study included consecutive patients with FTLD who underwent a clinical, cognitive, and behavioral assessment. The presence and severity of hyperorality was assessed using the Frontal Behavior Inventory.

Results: A total of 712 patients with FTLD were included in the study. Hyperorality was reported by 29% (204 of 712 [95% CI: 25-32%]) of patients; was more frequent in those with severe dementia than in those with prodromal or mild to moderate dementia (P < 0.05); was associated with younger age (odds ratio [OR] = 0.96 [95% CI: 0.94-0.99]), (P = 0.003) and positive family history for dementia (OR = 2.03 [95% CI: 1.18-3.49], P = 0.010); was overall more probable in the behavioral variant of frontotemporal dementia (bvFTD) and frontotemporal dementia with amyotrophic lateral sclerosis phenotypes, and less probable in other language or motor phenotypes; and was associated with higher severity of neuropsychiatric symptoms (OR = 1.08 [95% CI: 1.06-1.10], P < 0.001) and with the presence of several behavioral symptoms (P < 0.05). Moreover, hyperorality severity increased over time only in patients with bvFTD (β = +0.15, P = 0.011) or semantic variant of primary progressive aphasia (β = +0.34, P = 0.010). Finally, the presence of hyperorality was significantly associated with greater atrophy in the right anterior insula and right orbitofrontal region (false discovery rate-corrected P < 0.05).

Conclusion: Hyperorality is common in certain FTLD-associated syndromes. Understanding its correlates can help clinicians define pharmacological and educational interventions and clarify related anatomical circuits.

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与额颞叶变性相关的综合征中过度性的临床和影像学相关性。
目的:对额颞叶变性(FTLD)相关综合征中的过度性的实证研究十分有限。本研究旨在评估和描述FTLD相关综合征患者的黑质及其临床和影像学相关性:这项回顾性纵向研究包括连续接受临床、认知和行为评估的 FTLD 患者。结果:共有712名FTLD患者接受了临床、认知和行为评估:研究共纳入了 712 名 FTLD 患者。29%的患者(712 人中有 204 人[95% CI:25%-32%])报告了额叶行为异常;重度痴呆患者的额叶行为异常发生率高于前驱期痴呆或轻度至中度痴呆患者(P 结论:额叶行为异常在某些 FTLD 患者中很常见:在某些与 FTLD 相关的综合征中,脑功能亢进很常见。了解其相关性有助于临床医生确定药物和教育干预措施,并阐明相关的解剖回路。
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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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