Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Saudi Medical Journal Pub Date : 2024-10-01 DOI:10.15537/smj.2024.45.10.20240308

Jamil M Obaid, Sultan A Saghir, Amir M Al-Hroob, Shaima A Mohammed, Ola'a A Melhi, Ashgan A Alhomamy, Elham A Al-Qodaimi

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Abstract

Objectives: To ascertain the prevalence of ABH antigen secretors and non-secretors among Yemenis. In addition to explore the factors that may affect the expression of the secretion phenotype.

Methods: This cross-sectional study was carried out between May and September 2022 on 215 healthy Yemeni individuals at the International Malaysian University, Ibb, Yemen. The participants were tested for blood group antigen on their blood samples using standard test tube method using the suitable ABH antisera. Saliva was collected and tested for secretion using hemagglutination inhibition test with suitable A, B, and H antisera. Before collecting the blood samples, informed consent was obtained from each participant and complete data and history questionnaire were collected by the research team.

Results: In general, 78.1% of Yemini participants were found to be secretor (80% men and 73.3% females). This percentage increased within O blood group (95%) and decreased within AB blood group (54%) individuals. Both O and AB blood groups showed statistically significant association with secretor trait. Also, it was noticed that age advance increases the expression of Se gene. In addition, the secretor state increased among Rh-negative people.

Conclusion: The frequency of ABH secretors was 78.1% among Ibb province population in Yemen. Blood group O revealed the greatest frequency (95%), whereas blood group AB showed the lowest secretor frequency (54%). The secretor phenotype was highly expressed gradually with advance age then decline.

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随着 O 型血和年龄的增长，ABO 血型抗原分泌表型的表达增加。

目的确定也门人中 ABH 抗原分泌者和非分泌者的比例。此外，还探讨可能影响分泌表型表达的因素：这项横断面研究于 2022 年 5 月至 9 月期间在也门伊卜的马来西亚国际大学对 215 名健康的也门人进行。采用标准试管法，使用合适的 ABH 抗原对参与者的血液样本进行血型抗原检测。采集唾液后，使用合适的 A、B 和 H 抗原通过血凝抑制试验检测唾液分泌物。在采集血液样本前，研究小组征得了每位受试者的知情同意，并收集了完整的数据和病史问卷：总体而言，78.1% 的耶米尼参与者为分泌型（男性占 80%，女性占 73.3%）。这一比例在 O 型血人群中有所上升（95%），在 AB 型血人群中有所下降（54%）。从统计学角度看，O 型血和 AB 型血都与分泌物特质有显著关联。同时还发现，年龄的增长会增加 Se 基因的表达。此外，Rh 阴性人群中分泌物增多：也门伊卜省人口中 ABH 分泌者的频率为 78.1%。血型 O 的分泌者频率最高（95%），而血型 AB 的分泌者频率最低（54%）。随着年龄的增长，分泌物的表型逐渐增多，然后逐渐减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.