The association of liver fibrosis and chronic kidney disease in patients with metabolic associated fatty liver disease: A cross-sectional study.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Saudi Medical Journal Pub Date : 2024-10-01 DOI:10.15537/smj.2024.45.10.20240393

Rehab Badawi, Naglaa Samy Fahmy Abou Taira, Sara Essam Hasby, Walaa Elkhalawany, Waleed Elrefaey, Nahla Ahmed Khalf, Hanaa Ibrahim Okda

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Abstract

Objectives: To examine the relation between liver fibrosis and chronic kidney disease (CKD) in metabolic-associated fatty liver disease (MAFLD) patients and its risk factors.

Methods: The current study was carried out at Tanta University Hospital, Tanta, Egypt, from May 2021 to January 2023 and included 84 MAFLD patients with CKD and 80 MAFLD patients without CKD. All participants had been examined by abdominal ultrasonography and transient elastography with controlled attenuation parameter.

Results: Chronic kidney disease patients exhibited a greater incidence of fibrosis compared to patients without CKD (75.6% vs. 24.4%). Logistic analysis demonstrated that the presence of multiple health conditions, such as MAFLD, diabetes mellitus, hypertension, and cardiovascular disease, were individually linked to CKD. Gender and body mass index were not independent factors related to CKD. Additionally, factors such as age, hyperuricemia, hypertriglyceridemia, hypercholesterolemia, hypoalbuminemia, hyperbilirubinemia, and viral hepatitis, apart from MAFLD comorbidities, were independently linked to CKD.

Conclusion: Chronic kidney disease may represent a potential risk influence for liver fibrosis development in MAFLD patients.

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代谢相关性脂肪肝患者肝纤维化与慢性肾病的关系：横断面研究

目的研究代谢相关性脂肪肝（MAFLD）患者肝纤维化与慢性肾病（CKD）之间的关系及其风险因素：本研究于 2021 年 5 月至 2023 年 1 月在埃及坦塔的坦塔大学医院进行，包括 84 名患有慢性肾脏病的 MAFLD 患者和 80 名未患有慢性肾脏病的 MAFLD 患者。所有参与者都接受了腹部超声波检查和瞬态弹性成像（带控制衰减参数）检查：结果：与无慢性肾脏病的患者相比，慢性肾脏病患者的纤维化发生率更高（75.6% 对 24.4%）。逻辑分析表明，存在多种健康状况（如 MAFLD、糖尿病、高血压和心血管疾病）都与慢性肾脏病有关。性别和体重指数不是与慢性肾脏病相关的独立因素。此外，除 MAFLD 合并症外，年龄、高尿酸血症、高甘油三酯血症、高胆固醇血症、低白蛋白血症、高胆红素血症和病毒性肝炎等因素也与慢性肾脏病有独立联系：结论：慢性肾脏病可能是导致 MAFLD 患者肝纤维化的潜在风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.