Cytokine gene polymorphisms and suicide risk in an Indian ancestral population: A case-control study.

IF 3 4区 医学 Q2 PSYCHIATRY World Journal of Biological Psychiatry Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI:10.1080/15622975.2024.2410492
Ruchika Kaushik, Baibaswata Nayak, Bichitra Nanda Patra, Anna R Docherty, Andrey Shabalin, Chittaranjan Behera
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Abstract

Background: India currently accounts for a majority of global suicide deaths. Research in European ancestry has established that suicide mortality has a significant genetic component, and suggests that inflammation may play a crucial role in the pathophysiology of suicide. Inflammation is also highly relevant in regions of increased pollution exposure, such as the megacities of India. To address the existing gaps in genetic research on suicide and possible association with inflammatory biomarkers, we examined genetic polymorphism and clinical risk phenotypes in a population-based suicide-death cohort, India.

Material and methods: Genotyping of IL-1β(rs16944) & (rs1143627), IL-4(rs2070874), IL-6(rs1800795) and IL-10(rs1800896) was done in 234 post-mortem suicide-death cases and 256 post-mortem controls (N = 490) using PCR RFLP method.

Results: Our analyses identified three significant (p < 0.001) associations of cytokine variants with suicide death, including IL-1β(rs16944), OR = 0.627; IL-4(rs2070874), OR = 0.524; and IL-6(rs1800795), OR = 2.509. Cases were more likely female and were more likely to have a history of psychiatric illness, though rate of psychiatric illness was low in suicide cases(9%).

Conclusion: Our genetic results are generally consistent with previous research on risk for depression and suicidal behaviour, and both genetic and phenotypic results provide new insights into risk factors that may contribute to suicide in India.

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印度祖先人群中的细胞因子基因多态性与自杀风险:病例对照研究
背景:印度目前占全球自杀死亡人数的大多数。对欧洲血统的研究表明,自杀死亡率有很大的遗传因素,并表明炎症可能在自杀的病理生理学中起着至关重要的作用。在污染暴露增加的地区,如印度的大城市,炎症也与自杀密切相关。为了弥补现有自杀基因研究的不足以及与炎症生物标志物可能存在的关联,我们研究了印度基于人群的自杀死亡队列中的基因多态性和临床风险表型:采用 PCR RFLP 方法对 234 例自杀死亡病例和 256 例对照病例(N = 490)进行了 IL-1β(rs16944)和(rs1143627)、IL-4(rs2070874)、IL-6(rs1800795)和 IL-10(rs1800896)的基因分型:结果:我们的分析发现了三个显著的(p 结论:我们的研究结果与之前的研究结果基本一致:我们的遗传结果与之前关于抑郁症和自杀行为风险的研究结果基本一致,遗传和表型结果为了解可能导致印度人自杀的风险因素提供了新的视角。
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来源期刊
CiteScore
7.00
自引率
3.20%
发文量
73
审稿时长
6-12 weeks
期刊介绍: The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.
期刊最新文献
Exploring the anti-depressant effects and nitric oxide modulation of quercetin: A preclinical study in Socially Isolated mice. Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics. Cytokine gene polymorphisms and suicide risk in an Indian ancestral population: A case-control study. Correlations between alterations in global brain functional connectivity in patients with major depressive disorder and their genetic characteristics. Morphological correlates of anxiety-related experiences during a ketamine infusion.
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