Effect of alantolactones on cardiac parameters of animals under artificially induced oxidative stress.

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL BioMedicine-Taiwan Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI:10.37796/2211-8039.1457
Mishal Fatima, Hina Andleeb, Tanzila Rehman, Ouz Gul, Shanza Azeezz, Huzaifa Rehman, Haq Nawaz
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Abstract

Purpose: Phytochemicals have been found effective in reducing the oxidative stress and damage to cardiovascular and other tissues. In this study, the effects of alantolactone (AL) on cardiac parameters in rabbits exposed to artificially-induced oxidative stress were investigated.

Method: The oxidative stress was induced in a group of White New Zealand rabbits by injecting 40% hydrogen peroxide solution (1 ml/kg body weight) thrice with an interval of 72 h. The hydrogen peroxide-treated animals were orally treated with AL extracted from the roots of Inula helenium (1 ml/kg repeated thrice after 72 h). Blood samples were taken before and after the hydrogen peroxide and AL treatments, and the sera were subjected to analysis of oxidative damage in terms of malondialdehyde content (MDA), total antioxidant activity (TAOA), linoleic acid reduction capacity (LARC), hydroxyl radical scavenging capacity (HRSC), 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity (DPPH RSC), superoxide dismutase activity (SOD) and catalase activity, and cardiac parameters including troponin-I content (Trop-I), creatine kinase-MB (CKMB), aspartate transaminase (AST).

Results: The hydrogen peroxide treatment substantially enhanced MDA content and SOD activity and decreased LARC, HRSC, DPPH, and catalase activity. The AL treatment significantly decreased MDA content, TAOA, Trop-I, CK-MB, and AST levels and increased LARC, DPPH RSC, HRSC, and catalase activity.

Conclusion: The observed effect of AL treatment on the animals' oxidative stress, antioxidant status, and cardiac biomarkers emphasizes that AL may effectively manage oxidative stress and cardiac damage.

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金刚烷内酯对人工诱导氧化应激下动物心脏参数的影响
目的:植物化学物质可有效减少氧化应激和对心血管及其他组织的损伤。本研究探讨了金刚烷内酯(AL)对人工诱导氧化应激的兔子心脏参数的影响:方法:通过注射 40% 过氧化氢溶液(1 毫升/千克体重)三次,每次间隔 72 小时,诱导一组新西兰白兔产生氧化应激。在过氧化氢和 AL 处理前后采集血样,并对血清中的丙二醛含量(MDA)、总抗氧化活性(TAOA)、亚油酸还原能力(LARC)进行氧化损伤分析、氢氧自由基清除能力(HRSC)、2,2-二苯基-1-苦基肼自由基清除能力(DPPH RSC)、超氧化物歧化酶活性(SOD)和过氧化氢酶活性,以及包括肌钙蛋白-I 含量(Trop-I)、肌酸激酶-MB(CKMB)和天冬氨酸转氨酶(AST)在内的心脏参数。结果显示双氧水处理大大提高了 MDA 含量和 SOD 活性,降低了 LARC、HRSC、DPPH 和过氧化氢酶活性。AL处理明显降低了MDA含量、TAOA、Trop-I、CK-MB和AST水平,提高了LARC、DPPH RSC、HRSC和过氧化氢酶活性:结论:AL 治疗对动物氧化应激、抗氧化状态和心脏生物标志物的观察结果表明,AL 可有效控制氧化应激和心脏损伤。
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来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
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