A Novel Nutrition-Related Prognostic Biomarker for Predicting Survival in Patients with Colorectal Cancer.

IF 2 4区医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-10-09 DOI:10.1080/01635581.2024.2412356

Hao Cai, Yu Chen, Jian-Cheng Li, Yu-Xin Wang, An-Kang Chen, Hou-Jun Jia

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Abstract

Background: Colorectal cancer (CRC) is a prevalent global malignancy with substantial morbidity and mortality. Accurate prognostic evaluation is essential in CRC patient management. This study investigates the prognostic significance of red blood cell count (RBC) and Onodera's prognostic nutritional index (OPNI) in resectable CRC patients.

Methods: A retrospective analysis of 210 CRC patients undergoing radical resection (January 2015-January 2017) assessed clinical and hematological factors, including RBC, albumin, hemoglobin, and OPNI. A novel comprehensive biomarker, R-OPNI, combining preoperative RBC with OPNI, was introduced. Correlations with patient survival were analyzed, and R-OPNI's independent prognostic value was assessed through univariate and multivariate Cox models. Predictive ability was compared to other factors using the receiver operating characteristic (ROC) method.

Results: Higher RBC levels (≥ 3.9 × 10¹²/L) and elevated OPNI were associated with significantly improved overall survival. Lower R-OPNI scores (0 or 1) indicated notably poorer survival. Multivariate analysis confirmed R-OPNI's independent prognostic significance (HR: 0.273, 95% CI: 0.098-0.763, p = 0.013). R-OPNI (AUC = 0.732) demonstrated superior predictive value compared to individual prognostic factors.

Conclusion: R-OPNI emerges as a robust, independent prognostic predictor for resectable CRC patients, emphasizing the importance of assessing preoperative nutritional status.

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预测结直肠癌患者生存期的新型营养相关预后生物标记物

背景：结直肠癌（CRC）是一种全球流行的恶性肿瘤，发病率和死亡率都很高。准确的预后评估对 CRC 患者的管理至关重要。本研究探讨了红细胞计数（RBC）和小野寺预后营养指数（OPNI）在可切除 CRC 患者中的预后意义：对210例接受根治性切除术的CRC患者（2015年1月至2017年1月）进行回顾性分析，评估临床和血液学因素，包括RBC、白蛋白、血红蛋白和OPNI。引入了一种新的综合生物标志物--R-OPNI，将术前RBC与OPNI相结合。分析了R-OPNI与患者生存期的相关性，并通过单变量和多变量Cox模型评估了R-OPNI的独立预后价值。采用接收者操作特征（ROC）法比较了R-OPNI与其他因素的预测能力：结果：较高的 RBC 水平（≥ 3.9 × 1012/L）和 OPNI 升高与总生存率显著改善相关。R-OPNI评分越低（0或1），生存率越低。多变量分析证实了 R-OPNI 的独立预后意义（HR：0.273，95% CI：0.098-0.763，p = 0.013）。与单个预后因素相比，R-OPNI（AUC = 0.732）具有更高的预测价值：结论：R-OPNI 是可切除 CRC 患者强有力的独立预后预测因子，强调了评估术前营养状况的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.