Natural hydroxyapatite-based nanobiocomposites and their biomaterials-to-cell interaction for bone tissue engineering

IF 5.5 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanoscale Research Letters Pub Date : 2024-10-07 DOI:10.1186/s11671-024-04119-0
Jayachandran Venkatesan, Rowena Valeen Anchan, Sesha Subramanian Murugan, Sukumaran Anil, Se-Kwon Kim
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Abstract

Hydroxyapatite (HA) is an extensively used biomaterial for dental and orthopaedic applications because of its biocompatibility and biomimetic nature. HA is extensively used as a bone-graft substitute. HA bone graft substitutes of bovine or synthetic origins have been extensively studied. However, caprine-based HA has not been explored. In this study, we aimed to determine the utilization of goat bone-derived HA for commercial applications. HA from caprine bone and teeth was isolated using thermal calcination. The developed HA can be used as a bone graft substitute. Chemical characterization of the isolated HA was carried out using Fourier transform infrared spectroscopy, X-Ray Diffraction, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. The biocompatibility and apatite formation of isolated HA were assessed using MG-63 cells, MC3T3-E1, L929 cells, MSCs, adipose derived stem cells, human dermal tissue derived fibroblast cells and osteoblast-like cell line, The studies demonstrate that HA support cell adhesion and osteogenic properties. To improve sheep, lamp, or caprine bone-derived HA, several other composites have been developed with MgO2, ZrO2, ZnO2, and other polymeric substances. 3D printed technology was used to develop a bioink using sheep-derived HA and printed the composite scaffold as a bone graft substitute. Furthermore, the biomedical applications of sheep-derived HA been studied in terms of their antimicrobial activity, bone-forming ability, and wound healing applications. Sheep-, goat-, and caprine-derived HA are still underutilized and require further research to develop commercial possibilities and sustainable raw materials for HA-based bone graft substitutes.

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用于骨组织工程的天然羟基磷灰石基纳米生物复合材料及其生物材料与细胞的相互作用。
羟基磷灰石(HA)具有生物相容性和生物仿生性,是一种广泛应用于牙科和整形外科的生物材料。HA 被广泛用作骨移植替代物。牛源性或合成的 HA 骨移植替代物已被广泛研究。然而,以毛果芸香碱为基础的 HA 尚未得到研究。在这项研究中,我们旨在确定山羊骨源性 HA 在商业应用中的使用情况。通过热煅烧从山羊骨和牙齿中分离出了 HA。开发出的 HA 可用作骨移植替代物。利用傅立叶变换红外光谱、X 射线衍射、拉曼光谱、扫描电子显微镜和透射电子显微镜对分离出的 HA 进行了化学表征。使用 MG-63 细胞、MC3T3-E1 细胞、L929 细胞、间充质干细胞、脂肪衍生干细胞、人体真皮组织衍生成纤维细胞和类成骨细胞系对分离的 HA 的生物相容性和磷灰石形成进行了评估。为了改进绵羊、灯泡或山羊骨源性 HA,还开发了几种含有 MgO2、ZrO2、ZnO2 和其他聚合物物质的复合材料。利用三维打印技术开发了一种使用羊源性 HA 的生物墨水,并打印了复合支架作为骨移植替代物。此外,还从抗菌活性、成骨能力和伤口愈合应用等方面研究了羊源性 HA 的生物医学应用。绵羊、山羊和黄羊提取的 HA 仍未得到充分利用,需要进一步研究,以开发基于 HA 的骨移植替代品的商业可能性和可持续原材料。
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来源期刊
Nanoscale Research Letters
Nanoscale Research Letters 工程技术-材料科学:综合
CiteScore
11.30
自引率
0.00%
发文量
110
审稿时长
48 days
期刊介绍: Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.
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