Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study

IF 4.5 2区医学 Q1 GERIATRICS & GERONTOLOGY Journal of the American Geriatrics Society Pub Date : 2024-10-09 DOI:10.1111/jgs.19210

Jim Q. Ho MD, Ware G. Kuschner MD, Joe Verghese MBBS, MS

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Abstract

Background

Poor respiratory function, including low peak expiratory flow (PEF), is a risk factor for dementia. Motoric cognitive risk syndrome (MCR) is a predementia syndrome characterized by slow gait and subjective cognitive complaints. However, the association between PEF and MCR remains unclear. This study examined the cross-sectional and longitudinal association between PEF and MCR.

Methods

The National Health and Aging Trends Study (NHATS), which is a nationally representative cohort of adults ≥65 years of age in the United States, was analyzed from 2011 to 2017. Logistic regression and discrete-time proportional hazards models tested the association of PEF standardized residuals (SR) at baseline with prevalent and incident MCR, respectively. The models adjusted for multiple sociodemographic and health-related covariates.

Results

Among 5328 participants (57% women) included at baseline, lower PEF SR was associated with higher prevalence of MCR. Compared with the ≥80 PEF SR percentile group, the <30 and 30–50 percentile groups had significantly higher odds of prevalent MCR (OR 3.04 [95% CI 1.85, 5.01]; OR 2.06 [95% CI 1.19, 3.54], respectively). Over six years of follow-up, lower PEF SR was also associated with higher incidence of MCR. Compared with the ≥80 PEF SR percentile group, the <30 and 30–50 percentile groups had significantly higher risk of incident MCR (HR 1.81 [95% CI 1.24, 2.66]; HR 1.55 [95% CI 1.02, 2.34], respectively).

Conclusions

Lower PEF was associated with higher prevalence and incidence of MCR. Poor respiratory function should be further investigated as a potentially modifiable risk factor for MCR and cognitive decline.

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峰值呼气流量可预测运动性认知风险综合征：一项队列研究

背景：呼吸功能不良，包括呼气峰值流量（PEF）低，是痴呆症的一个危险因素。运动性认知风险综合征（MCR）是一种痴呆前期综合征，以步态缓慢和主观认知症状为特征。然而，PEF 与 MCR 之间的关系仍不清楚。本研究探讨了PEF与MCR之间的横向和纵向关系：研究分析了 2011 年至 2017 年的美国全国健康与老龄化趋势研究（NHATS），该研究是美国≥65 岁成年人的全国代表性队列。逻辑回归模型和离散时间比例危险模型分别检验了基线PEF标准化残差（SR）与MCR患病率和发病率的关系。这些模型对多种社会人口学和健康相关协变量进行了调整：在基线时纳入的 5328 名参与者（57% 为女性）中，较低的 PEF SR 与较高的 MCR 患病率相关。结论：与 PEF SR 百分位数≥80 的人群相比，PEF SR 百分位数越低，MCR 患病率越高：较低的 PEF 与较高的 MCR 患病率和发病率有关。呼吸功能不良可能是导致 MCR 和认知能力下降的一个可改变的风险因素，应对此进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Geriatrics Society 医学-老年医学

CiteScore

10.00

自引率

6.30%

发文量

504

审稿时长

3-6 weeks

期刊介绍： Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.