Efficacité de 6 scénarios de décontamination de bras de fauteuils contaminés volontairement au cyclophosphamide.

The Canadian journal of hospital pharmacy Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI:10.4212/cjhp.3588
Mathilde Dupré, Manon Marc, Jean-François Bussières
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Abstract

Background: The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.

Objective: To evaluate the effectiveness of decontamination scenarios.

Methods: This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm2).

Results: Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (n = 18), 99.90% (SD 0.15%) after 2 cleanses (n = 18), and 99.95% (SD 0.06%) after 3 cleanses (n = 15).

Conclusion: The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.

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对故意沾染环磷酰胺的椅子扶手进行净化的 6 种方案的有效性。
背景:肿瘤门诊椅子的扶手经常被环磷酰胺污染:肿瘤门诊的椅子扶手经常受到环磷酰胺的污染:评估净化方案的有效性:这是一项描述性模拟研究,针对硅胶织物表面被 10 μg 环磷酰胺污染的 6 个去污方案进行了研究。使用微纤维抹布擦拭测试的去污产品(季铵盐、0.5% 过氧化氢、0.005% 洗涤剂和 0.5% 次氯酸钠)。使用超高效液相色谱-串联质谱系统测量残留污染,环磷酰胺的检测和定量限(0.0006 ng/cm2)完全相同:在 59 份样本中,3 份空白样本为阴性,5 份样本可测量回收率(93.7% [标准偏差 4.6%]),51 份样本为实验样本。药剂的平均效率大于或等于 99.79%。无论使用哪种药剂,经过 1 次清洗(n = 18)后的有效率为 99.30%(标准差为 1.20%),经过 2 次清洗(n = 18)后的有效率为 99.90%(标准差为 0.15%),经过 3 次清洗(n = 15)后的有效率为 99.95%(标准差为 0.06%):结论:6 种净化方案均有效。结论:6 种净化方案均有效。
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