Flexible sensing probe for the simultaneous monitoring of neurotransmitters imbalance

IF 4.7 Q2 NANOSCIENCE & NANOTECHNOLOGY Micro and Nano Systems Letters Pub Date : 2024-10-08 DOI:10.1186/s40486-024-00211-3
Hye Bin Cha, Yao Zhang, Hyun-Yong Yu, Yi Jae Lee
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Abstract

Simultaneous detection of multiple neurotransmitters and their related activities is crucial for enhancing our understanding of complex neurological mechanisms and disorders. In this study, we developed a flexible, high-sensitivity multi-electrodes array probe capable of concurrent detection of four neurotransmitters: dopamine, serotonin, acetylcholine and glutamate. The probe was fabricated on a polyimide substrate with 16 circular gold-film electrodes. These electrodes were modified with PEDOT/GluOx and PEDOT/ChOx for enzymatic detection of glutamate and acetylcholine, and with rGO/PEDOT/Nafion for the detection of dopamine and serotonin. Our electrochemical sensor achieved sensitivities of 184.21 and 219.29 μA/μM cm2 for glutamate and acetylcholine, respectively, with limits of detection (LOD) of 0.0242 and 0.0351 μM within a concentration range of 0.1–100 μM. For dopamine and serotonin, the sensor showed sensitivities of 195.9 and 181.2 μA/μM cm2, respectively, with LOD of 0.4743 and 0.3568 μM. This research advances the field of neurochemical sensing and provides valuable insights into the balance of neurotransmitters associated with neurological disorders. These insights improve diagnostic and therapeutic strategies.

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用于同时监测神经递质失衡的柔性传感探针
同时检测多种神经递质及其相关活动对于加深我们对复杂神经机制和疾病的了解至关重要。在这项研究中,我们开发了一种灵活、高灵敏度的多电极阵列探针,能够同时检测四种神经递质:多巴胺、血清素、乙酰胆碱和谷氨酸。该探针是在聚酰亚胺基底上制作的,带有 16 个圆形金膜电极。这些电极用 PEDOT/GluOx 和 PEDOT/ChOx 修饰,用于谷氨酸和乙酰胆碱的酶检测;用 rGO/PEDOT/Nafion 修饰,用于多巴胺和血清素的检测。我们的电化学传感器对谷氨酸和乙酰胆碱的灵敏度分别为 184.21 和 219.29 μA/μM cm2,在 0.1-100 μM 浓度范围内的检出限(LOD)分别为 0.0242 和 0.0351 μM。对于多巴胺和血清素,传感器的灵敏度分别为 195.9 和 181.2 μA/μM cm2,检测限分别为 0.4743 和 0.3568 μM。这项研究推动了神经化学传感领域的发展,并为了解与神经系统疾病相关的神经递质平衡提供了宝贵的见解。这些见解改进了诊断和治疗策略。
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来源期刊
Micro and Nano Systems Letters
Micro and Nano Systems Letters Engineering-Biomedical Engineering
CiteScore
10.60
自引率
5.60%
发文量
16
审稿时长
13 weeks
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