Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-11-11 Epub Date: 2024-10-11 DOI:10.1021/acsbiomaterials.4c00756

Ling-Kun Zhang, Yuan Li, Limin Zhai, Yunzhi Tang, Yuxuan Jiao, Yitong Mei, Runcai Yang, Rong You, Liang Yin, He Ni, Jian Ge, Yan-Qing Guan

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Abstract

The P53 gene is commonly mutated in breast cancer, protein based the gene as anticancer drugs could provide efficient and stable advantages by restoring the function of the wild-type P53 protein. In this study, we describe the creation and utilization of a micelle composed by natural phycocyanin and paclitaxel and grafting anti-HER2 (PPH), which effectively packages and transports recombinant P53 protein with anti-ER (PE), resulting in a new entity designated as PE@PPH, to address localization obstacles and modify cellular tropism to the cell membrane or nucleus. The results indicate that PE@PPH has strong antitumor properties, even at low doses of PTX both in vitro and in vivo. These findings suggest that PE@PPH could be an enhancing micelle for delivering therapeutic proteins and promoting protein functional recovery, particularly in addressing the challenges posed by tumor heterogeneity in breast cancer.

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天然植物花青素/紫杉醇胶束释放治疗性 P53，激活 HER2 或 ER 阳性乳腺癌的细胞凋亡。

P53 基因是乳腺癌中常见的突变基因，基于该基因的蛋白质作为抗癌药物，可以通过恢复野生型 P53 蛋白的功能，提供高效、稳定的优势。在这项研究中，我们介绍了一种由天然植物花青素和紫杉醇组成的胶束的创建和利用，以及抗 HER2（PPH）的接枝，这种胶束能有效地将重组 P53 蛋白与抗 HER（PE）包装和运输，形成一种新的实体，命名为 PE@PPH，以解决定位障碍并改变细胞对细胞膜或细胞核的趋向性。研究结果表明，PE@PPH 具有很强的抗肿瘤特性，即使在体外和体内使用低剂量 PTX 时也是如此。这些研究结果表明，PE@PPH 可作为一种增强型胶束，用于递送治疗蛋白和促进蛋白功能恢复，特别是在应对乳腺癌肿瘤异质性带来的挑战方面。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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