Hydrogel System with Independent Tailoring of Mechanics, CT, and US Contrasts for Affordable Medical Phantoms.

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2024-09-26 eCollection Date: 2024-10-07 DOI:10.1021/acsmaterialslett.4c01660

Haoyi Qiu, Jakob Nazarenus, Bernhard Egeler, Tom Thode, Firdaws Osman, Daniar Osmonov, Jörg Bahr, Sören Kaps, Frank-Andre Siebert, Reinhard Koch, Ulf Lützen, Rainer Adelung, Leonard Siebert

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Abstract

Medical phantoms mimic aspects of procedures like computed tomography (CT), ultrasound (US) imaging, and surgical practices. However, the materials for current commercial phantoms are expensive and the fabrication with these is complex and lacks versatility. Therefore, existing material solutions are not suitable for creating patient-specific phantoms. We present a novel and cost-effective material system (utilizing ubiquitous sodium alginate hydrogel and coconut fat) with independently and accurately tailorable CT, US, and mechanical properties. By varying the concentration of alginate, cross-linker, and coconut fat, the radiological parameters and the elastic modulus were adjusted independently in a wide range. The independence was demonstrated by creating phantoms with features hidden in US, while visible in CT imaging and vice versa. This system is particularly beneficial in resource-scarce areas since the materials are cheap (<$ 1 USD/kg) and easy to obtain, offering realistic and versatile phantoms to practice surgeries and ultimately enhance patient care.

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水凝胶系统可独立调整力学、CT 和 US 对比度，实现经济实惠的医学模型。

医学模型可以模拟计算机断层扫描（CT）、超声波（US）成像和外科手术等程序的各个方面。然而，目前的商用模型材料价格昂贵，而且制作工艺复杂，缺乏通用性。因此，现有的材料解决方案并不适合制作病人专用模型。我们提出了一种新颖且经济高效的材料系统（利用无处不在的海藻酸钠水凝胶和椰子脂肪），它具有独立且可精确定制的 CT、US 和机械性能。通过改变海藻酸钠、交联剂和椰子脂肪的浓度，放射学参数和弹性模量可在很大范围内独立调整。通过创建在 US 中隐藏特征、而在 CT 成像中可见的模型，反之亦然，证明了这种独立性。该系统尤其适用于资源匮乏的地区，因为材料便宜 (

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.