Mediation of genetic susceptibility to obesity through eating behaviours in children.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-10-10 DOI:10.1111/ijpo.13180

Danick Goulet, Michel Boivin, Christopher A Gravel, Julian Little, Beth K Potter, Lise Dubois

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Abstract

Background/objectives: Few studies have examined the putative mediating role of eating behaviours linking genetic susceptibility and body weight. The goal of this study was to investigate the extent to which two polygenic scores (PGSs) for body mass index (BMI), based on child and adult data, predicted BMI through over-eating and fussy eating across childhood.

Subjects/methods: The study sample involved 692 participants from a birth cohort study. Height and weight were measured on six occasions between ages 6 and 13 years. Over-eating and fussy eating behaviours were assessed five times between ages 2 and 6 years. Longitudinal growth curve mediation analysis was used to estimate the contributions of the PGSs to BMI z-scores mediated by over-eating and fussy eating.

Results: Both PGSs predicted BMI z-scores (PGS_child: β = 0.26, 95% CI: 0.19-0.33; PGS_adult: β = 0.34, 95% CI: 0.27-0.41). Over-eating significantly mediated these associations, but this mediation decreased over time from 6 years (PGS_child: 18.0%, 95% CI: 3.1-32.9, p-value = 0.018; PGS_adult: 14.2%, 95% CI: 2.8-25.5, p-value = 0.014) to 13 years (PGS_child: 11.4%, 95% CI: -0.4-23.1, p-value = 0.057; PGS_adult: 6.2%, 95% CI: 0.4-12.0, p-value = 0.037). Fussy eating did not show any mediation.

Conclusions: Our results support the view that appetite is key to translating genetic susceptibility into changes in body weight.

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儿童饮食行为对肥胖遗传易感性的调节作用。

背景/目的：很少有研究探讨饮食行为在遗传易感性和体重之间的潜在中介作用。本研究的目的是根据儿童和成人的数据，调查身体质量指数（BMI）的两个多基因评分（PGSs）在多大程度上通过儿童时期的过度进食和挑食来预测身体质量指数：研究样本包括一项出生队列研究中的 692 名参与者。在 6 岁至 13 岁期间，对他们的身高和体重进行了六次测量。在 2 至 6 岁期间，对过度进食和挑食行为进行了 5 次评估。采用纵向生长曲线中介分析法估算了由过度进食和挑食行为中介的 PGS 对 BMI z 分数的贡献：结果：两个 PGS 均可预测体重指数 z 值（PGSchild：β = 0.26，95% CI：0.19-0.33；PGSadult：β = 0.34，95% CI：0.27-0.41）。过量进食对这些关联有明显的中介作用，但这种中介作用随着时间的推移从 6 岁开始逐渐减弱（PGSchild：18.0%，95% CI：3.1-32.9，p 值 = 0.018；PGSadult：14.2%，95% CI：2.8-25.5，p 值 = 0.014）到 13 岁（PGSchild：11.4%，95% CI：-0.4-23.1，p 值 = 0.057；PGSadult：6.2%，95% CI：0.4-12.0，p 值 = 0.037）。挑剔饮食没有显示出任何中介作用：我们的研究结果支持这样一种观点，即食欲是将遗传易感性转化为体重变化的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.