Genomic characteristics of human respiratory syncytial virus from children in China during 2017-2020

IF 2.5 4区 医学 Q3 VIROLOGY Archives of Virology Pub Date : 2024-10-10 DOI:10.1007/s00705-024-06138-9
Fei Li, Yun Zhu, Qiuping Li, Xiaolei Guan, Hailin Zhang, Changchong Li, Meng Zhang, Lei Li, Yiliang Fu, Yali Duan, Luci Huang, Zhengde Xie, Xiangpeng Chen
{"title":"Genomic characteristics of human respiratory syncytial virus from children in China during 2017-2020","authors":"Fei Li,&nbsp;Yun Zhu,&nbsp;Qiuping Li,&nbsp;Xiaolei Guan,&nbsp;Hailin Zhang,&nbsp;Changchong Li,&nbsp;Meng Zhang,&nbsp;Lei Li,&nbsp;Yiliang Fu,&nbsp;Yali Duan,&nbsp;Luci Huang,&nbsp;Zhengde Xie,&nbsp;Xiangpeng Chen","doi":"10.1007/s00705-024-06138-9","DOIUrl":null,"url":null,"abstract":"<div><p>Acute lower respiratory tract infections (ALRTIs) are a leading cause of mortality in young children worldwide due to human respiratory syncytial virus (RSV). The aim of this study was to monitor genetic variations in RSV and provide genomic data support for RSV prevention and control. A total of 105 complete RSV genome sequences were determined during 2017-2020. Phylogenetic analysis showed that all of the RSVA sequences were of genotype ON1, and all of the RSVB sequences were of genotype BA9. Notably, a phylogenetic tree based on the whole genome had more branches than a tree based on the G gene. In comparison to the RSV prototype sequences, 71.43% (50/70) of the ON1 sequences had five amino acid substitutions (T113I, V131N, N178G, H258Q, and H266L) that occurred simultaneously, and 68.57% (24/35) of the BA9 genotype sequences had 12 amino acid substitutions, four of which (A131T, T137I, T288I, and T310I) occurred simultaneously. In the F gene, there were 19 amino acid substitutions, which were mainly located in the antigenic sites Ø, II, V, and VII. Other amino acid substitutions were found in the NS1, NS2, P, SH, and L proteins. No significant evidence of recombination was found in any of the sequences. These findings provide important data that will be useful for prevention, control, and vaccine development against RSV.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 11","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Virology","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00705-024-06138-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Acute lower respiratory tract infections (ALRTIs) are a leading cause of mortality in young children worldwide due to human respiratory syncytial virus (RSV). The aim of this study was to monitor genetic variations in RSV and provide genomic data support for RSV prevention and control. A total of 105 complete RSV genome sequences were determined during 2017-2020. Phylogenetic analysis showed that all of the RSVA sequences were of genotype ON1, and all of the RSVB sequences were of genotype BA9. Notably, a phylogenetic tree based on the whole genome had more branches than a tree based on the G gene. In comparison to the RSV prototype sequences, 71.43% (50/70) of the ON1 sequences had five amino acid substitutions (T113I, V131N, N178G, H258Q, and H266L) that occurred simultaneously, and 68.57% (24/35) of the BA9 genotype sequences had 12 amino acid substitutions, four of which (A131T, T137I, T288I, and T310I) occurred simultaneously. In the F gene, there were 19 amino acid substitutions, which were mainly located in the antigenic sites Ø, II, V, and VII. Other amino acid substitutions were found in the NS1, NS2, P, SH, and L proteins. No significant evidence of recombination was found in any of the sequences. These findings provide important data that will be useful for prevention, control, and vaccine development against RSV.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
2017-2020年中国儿童人呼吸道合胞病毒的基因组特征。
急性下呼吸道感染(ALRTIs)是人类呼吸道合胞病毒(RSV)导致全球幼儿死亡的主要原因。本研究旨在监测 RSV 的基因变异,为 RSV 的预防和控制提供基因组数据支持。2017-2020年间,共测定了105个完整的RSV基因组序列。系统进化分析表明,所有的RSVA序列均为基因型ON1,所有的RSVB序列均为基因型BA9。值得注意的是,基于全基因组的系统发生树比基于 G 基因的系统发生树有更多的分支。与 RSV 原型序列相比,71.43%(50/70)的 ON1 序列有 5 个同时发生的氨基酸置换(T113I、V131N、N178G、H258Q 和 H266L),68.57%(24/35)的 BA9 基因型序列有 12 个氨基酸置换,其中 4 个(A131T、T137I、T288I 和 T310I)同时发生。在 F 基因中,有 19 个氨基酸置换,主要位于抗原位点 Ø、II、V 和 VII。其他氨基酸替换出现在 NS1、NS2、P、SH 和 L 蛋白中。在任何序列中都没有发现重组的重要证据。这些发现为 RSV 的预防、控制和疫苗开发提供了重要数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Archives of Virology
Archives of Virology 医学-病毒学
CiteScore
5.10
自引率
7.40%
发文量
324
审稿时长
4.5 months
期刊介绍: Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.
期刊最新文献
Can viral proteins be retooled for chimeric toxin development? Characterization of two Campylobacter jejuni phages and evaluation of their antibacterial efficacy with EDTA Association of IL1RN VNTR and NKG2A polymorphisms with hepatitis E infection, a case study from western India Genomic characteristics of a novel non-segmented double-stranded RNA mycovirus from the fungus Nigrospora oryzae Complete genome sequence of a rare recombinant GII.5[P16] norovirus found in Russian Siberia
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1