Causal relationships between cerebral cortical structure and preeclampsia: insights from bidirectional Mendelian randomization and colocalization analysis.

IF 2.9 2区 医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-10-03 DOI:10.1093/cercor/bhae400
Qiong Liu, Shaoqing Jiang, Yan Li, Aiyin Zhou, Hanfan Long, Weifen Zhong
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Abstract

Preeclampsia, a multifaceted condition characterized by high blood pressure during pregnancy, is linked to substantial health risks for both the mother and the fetus. Previous studies suggest potential neurological impacts, but the causal relationships between cortical structural changes and preeclampsia remain unclear. We utilized genome-wide association study data for cortical thickness (TH) and surface area (SA) across multiple brain regions and preeclampsia. Bidirectional Mendelian randomization (MR) analyses were conducted to assess causality, followed by co-localization analyses to confirm shared genetic architecture. Increased cortical TH in the inferior parietal and supramarginal regions, and an enlarged SA in the postcentral region, were significantly associated with higher preeclampsia risk. Conversely, preeclampsia was linked to increased SA in the supramarginal and middle temporal gyri, and decreased SA in the lingual gyrus. Co-localization analyses indicated distinct genetic determinants for cortical structures and preeclampsia. Our findings reveal bidirectional influences between cortical structural features and preeclampsia, suggesting neuroinflammatory and vascular mechanisms as potential pathways. These insights underscore the importance of considering brain structure in preeclampsia risk assessment and highlight the need for further research into neuroprotective strategies.

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大脑皮层结构与子痫前期之间的因果关系:双向孟德尔随机化和共聚焦分析的启示。
子痫前期是一种以妊娠期高血压为特征的多发性疾病,对母亲和胎儿的健康都有很大风险。以往的研究表明,先兆子痫对神经系统有潜在影响,但大脑皮层结构变化与先兆子痫之间的因果关系仍不清楚。我们利用全基因组关联研究数据,研究了多个脑区的皮质厚度(TH)和表面积(SA)与子痫前期的关系。我们进行了双向孟德尔随机化(MR)分析以评估因果关系,随后又进行了共定位分析以确认共同的遗传结构。下顶叶区和上边缘区皮层TH的增加以及后中央区SA的增大与子痫前期风险的增加有显著相关性。相反,子痫前期则与边上回和颞中回的SA增加以及舌回的SA减少有关。共定位分析表明,大脑皮层结构和子痫前期有不同的遗传决定因素。我们的研究结果揭示了大脑皮层结构特征与子痫前期之间的双向影响,表明神经炎症和血管机制是潜在的途径。这些见解强调了在子痫前期风险评估中考虑大脑结构的重要性,并突出了进一步研究神经保护策略的必要性。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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