首页 > 最新文献

Cerebral cortex最新文献

英文 中文
Developmental encoding of natural sounds in the mouse auditory cortex. 小鼠听觉皮层对自然声音的发育编码
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae438
Stefano Zucca, Chiara La Rosa, Tommaso Fellin, Paolo Peretto, Serena Bovetti

Mice communicate through high-frequency ultrasonic vocalizations, which are crucial for social interactions such as courtship and aggression. Although ultrasonic vocalization representation has been found in adult brain areas along the auditory pathway, including the auditory cortex, no evidence is available on the neuronal representation of ultrasonic vocalizations early in life. Using in vivo two-photon calcium imaging, we analyzed auditory cortex layer 2/3 neuronal responses to USVs, pure tones (4 to 90 kHz), and high-frequency modulated sweeps from postnatal day 12 (P12) to P21. We found that ACx neurons are tuned to respond to ultrasonic vocalization syllables as early as P12 to P13, with an increasing number of responsive cells as the mouse age. By P14, while pure tone responses showed a frequency preference, no syllable preference was observed. Additionally, at P14, USVs, pure tones, and modulated sweeps activate clusters of largely nonoverlapping responsive neurons. Finally, we show that while cell correlation decreases with increasing processing of peripheral auditory stimuli, neurons responding to the same stimulus maintain highly correlated spontaneous activity after circuits have attained mature organization, forming neuronal subnetworks sharing similar functional properties.

小鼠通过高频超声波发声进行交流,这对求偶和攻击等社会互动至关重要。虽然在听觉通路的成年脑区(包括听觉皮层)发现了超声波发声表征,但没有证据表明超声波发声在生命早期的神经元表征。利用体内双光子钙成像技术,我们分析了听觉皮层第 2/3 层神经元对 USV、纯音(4 至 90 kHz)和高频调制扫频的反应。我们发现,ACx神经元早在出生后第12天至第13天就能对超声发声音节做出反应,随着小鼠年龄的增长,反应细胞的数量也在增加。到 P14 时,虽然纯音反应显示出频率偏好,但没有观察到音节偏好。此外,在 P14 时,USV、纯音和调制扫频激活的反应神经元群基本不重叠。最后,我们发现,虽然细胞相关性会随着外周听觉刺激处理的增加而降低,但对相同刺激做出反应的神经元在电路组织成熟后仍会保持高度相关的自发活动,形成具有相似功能特性的神经元子网络。
{"title":"Developmental encoding of natural sounds in the mouse auditory cortex.","authors":"Stefano Zucca, Chiara La Rosa, Tommaso Fellin, Paolo Peretto, Serena Bovetti","doi":"10.1093/cercor/bhae438","DOIUrl":"10.1093/cercor/bhae438","url":null,"abstract":"<p><p>Mice communicate through high-frequency ultrasonic vocalizations, which are crucial for social interactions such as courtship and aggression. Although ultrasonic vocalization representation has been found in adult brain areas along the auditory pathway, including the auditory cortex, no evidence is available on the neuronal representation of ultrasonic vocalizations early in life. Using in vivo two-photon calcium imaging, we analyzed auditory cortex layer 2/3 neuronal responses to USVs, pure tones (4 to 90 kHz), and high-frequency modulated sweeps from postnatal day 12 (P12) to P21. We found that ACx neurons are tuned to respond to ultrasonic vocalization syllables as early as P12 to P13, with an increasing number of responsive cells as the mouse age. By P14, while pure tone responses showed a frequency preference, no syllable preference was observed. Additionally, at P14, USVs, pure tones, and modulated sweeps activate clusters of largely nonoverlapping responsive neurons. Finally, we show that while cell correlation decreases with increasing processing of peripheral auditory stimuli, neurons responding to the same stimulus maintain highly correlated spontaneous activity after circuits have attained mature organization, forming neuronal subnetworks sharing similar functional properties.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of left ventrolateral prefrontal stimulation on forming and maintaining deep and shallow episodic traces. 刺激左侧前额叶外侧对形成和维持深浅情节痕迹的影响
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae437
Nan Peng, Wei Wu, Sergio Della Sala, Paul Hoffman

The levels-of-processing framework, proposing that deep encoding enhances retention, plays a crucial role in episodic memory research. Neuroimaging evidence highlights that increased activity of the left ventrolateral prefrontal cortex during deep encoding predicts subsequent memory success. However, cognitive mechanisms underlying this region's involvement in establishing and consolidating deep and shallow traces remain unclear. In this preregistered study, we investigated whether repetitive transcranial magnetic stimulation over the left ventrolateral prefrontal cortex versus the vertex differentially modulates the formation and maintenance of deep and shallow traces. Trains of 20 Hz online repetitive transcranial magnetic stimulation were delivered over the left ventrolateral prefrontal cortex or vertex during tasks involving pleasantness (deep) and alphabetical order (shallow) judgments of words. Following encoding, two recognition tests assessed immediate and 24-h delayed recognition of words. Compared to the vertex control, ventrolateral prefrontal stimulation selectively disrupted the formation of episodic memory under deep encoding conditions, evidenced by increased response time at encoding and reduced immediate recognition in the deep but not shallow condition. Notably, forgetting rates across the 24-h delay were similar for disrupted deep, intact deep, and shallow items, implying that the rate of trace decay is independent of the strength of trace formation. The constant trace decay indicates that distinct mechanisms are involved in establishing and maintaining episodic traces.

处理水平框架提出深度编码能增强记忆的保持,这一框架在外显记忆研究中起着至关重要的作用。神经影像学证据表明,在深度编码过程中,左侧腹外侧前额叶皮层活动的增加预示着随后记忆的成功。然而,该区域参与建立和巩固深浅痕迹的认知机制仍不清楚。在这项预先登记的研究中,我们调查了重复经颅磁刺激左侧腹外侧前额叶皮层与顶点是否会对深浅痕迹的形成和维持产生不同的调节作用。在涉及单词愉快度(深层)和字母顺序(浅层)判断的任务中,对左侧腹外侧前额叶皮层或顶点进行一连串 20 赫兹的在线重复经颅磁刺激。编码后,两个识别测试分别评估了对单词的即时识别和 24 小时延迟识别。与顶点对照组相比,在深度编码条件下,前额叶外侧刺激选择性地破坏了外显记忆的形成,表现为编码时反应时间增加,以及在深度条件下即时识别率降低,而在浅度条件下则没有。值得注意的是,在24小时的延迟中,被破坏的深层、完整的深层和浅层项目的遗忘率相似,这意味着痕迹衰减的速度与痕迹形成的强度无关。恒定的痕迹衰减表明,在建立和维持情节性痕迹的过程中,有不同的机制参与其中。
{"title":"Effects of left ventrolateral prefrontal stimulation on forming and maintaining deep and shallow episodic traces.","authors":"Nan Peng, Wei Wu, Sergio Della Sala, Paul Hoffman","doi":"10.1093/cercor/bhae437","DOIUrl":"10.1093/cercor/bhae437","url":null,"abstract":"<p><p>The levels-of-processing framework, proposing that deep encoding enhances retention, plays a crucial role in episodic memory research. Neuroimaging evidence highlights that increased activity of the left ventrolateral prefrontal cortex during deep encoding predicts subsequent memory success. However, cognitive mechanisms underlying this region's involvement in establishing and consolidating deep and shallow traces remain unclear. In this preregistered study, we investigated whether repetitive transcranial magnetic stimulation over the left ventrolateral prefrontal cortex versus the vertex differentially modulates the formation and maintenance of deep and shallow traces. Trains of 20 Hz online repetitive transcranial magnetic stimulation were delivered over the left ventrolateral prefrontal cortex or vertex during tasks involving pleasantness (deep) and alphabetical order (shallow) judgments of words. Following encoding, two recognition tests assessed immediate and 24-h delayed recognition of words. Compared to the vertex control, ventrolateral prefrontal stimulation selectively disrupted the formation of episodic memory under deep encoding conditions, evidenced by increased response time at encoding and reduced immediate recognition in the deep but not shallow condition. Notably, forgetting rates across the 24-h delay were similar for disrupted deep, intact deep, and shallow items, implying that the rate of trace decay is independent of the strength of trace formation. The constant trace decay indicates that distinct mechanisms are involved in establishing and maintaining episodic traces.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization. 皮层结构变化与焦虑症发病之间的因果关系:孟德尔随机化的证据。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae440
Fei Teng, Mengqi Wang, Zhangyu Lu, Chunyu Zhang, Linglong Xiao, ZhaoMing Chen, Mengshuang Huang, Linglin Xie, Zheyu Chen, Wei Wang

Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891-0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987-0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000-1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.

以往的研究表明,焦虑症与大脑结构变化之间存在相关性,但大脑区域体积的具体变化仍不清楚。本研究旨在通过孟德尔随机分析法推断焦虑症与大脑结构体积变化之间的因果关系。我们从 GWAS 数据库中选取了 63 个皮层结构体积作为暴露数据,并从 FinnGen 和英国生物库数据库中选取焦虑症数据作为结果。我们发现,左侧前中央区体积萎缩(Odds Ratio [OR] = 0.935,95% 置信区间 [CI]:0.891-0.981)与焦虑症之间存在明显的相关性:0.891-0.981,P 值,P = 0.007)与焦虑症风险增加之间存在显著相关性。此外,在特定脑区发现的变化,如右侧喙状前扣带回区萎缩(OR = 0.993,95% CI:0.987-0.999,P = 0.025)和左侧上顶叶区体积增大(OR = 1.001,95% CI:1.000-1.001,P = 0.028),可能与焦虑症风险增加有关。此外,这两种表型在合并前后各自和总体的荟萃分析 OR 值中都表现出方向一致性,从而提高了结果的可靠性。这项研究阐明了焦虑症与特定大脑结构之间的因果关系,为进一步研究精神疾病提供了新的视角。
{"title":"Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization.","authors":"Fei Teng, Mengqi Wang, Zhangyu Lu, Chunyu Zhang, Linglong Xiao, ZhaoMing Chen, Mengshuang Huang, Linglin Xie, Zheyu Chen, Wei Wang","doi":"10.1093/cercor/bhae440","DOIUrl":"10.1093/cercor/bhae440","url":null,"abstract":"<p><p>Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891-0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987-0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000-1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered gait speed and brain network connectivity in Parkinson's disease. 帕金森病患者的步速和大脑网络连接发生改变
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae429
Shichan Wang, Yi Xiao, Yanbing Hou, Chunyu Li, Junyu Lin, Tianmi Yang, Ningning Che, Qirui Jiang, Xiaoting Zheng, Jiyong Liu, Huifang Shang

Slow gait speed and disrupted brain network connectivity are common in patients with Parkinson's disease (PD). This study aimed to clarify the relationship between gait speed and clinical characteristics in PD, and explore the underlying brain network mechanisms. Forty-two PD patients and 20 healthy controls (HC) were recruited. Statistical independent component analysis and correlation analysis were employed to investigate underlying neural mechanisms and relationships. PD patients exhibited significantly slower gait speed, which showed a significant negative correlation with postural instability and gait disturbance scores. Network connectivity analysis revealed decreased intranetwork functional connectivity (FC) within visual network (VN) and cerebellum network (CN), but increased internetwork FC between CN and both sensorimotor network (SMN) and frontoparietal network (FPN) in PD patients compared to HC. The slow gait speed PD subgroup demonstrated increased intranetwork FC within SMN and VN, along with decreased FC between VN and both FPN and default mode network. Correlation analyses revealed negative correlation between gait speed and FC of CN and positive correlation to FC of CN-SMN. Our study identified relationships between gait speed and clinical characteristics, and corresponding network connectivity alterations in PD patients, providing insights into the neural mechanisms underlying gait impairments in PD.

帕金森病(PD)患者普遍存在步速缓慢和大脑网络连接紊乱的问题。本研究旨在阐明帕金森病步态速度与临床特征之间的关系,并探索其潜在的脑网络机制。研究招募了42名帕金森病患者和20名健康对照组(HC)。采用独立成分统计分析和相关分析来研究潜在的神经机制和关系。帕金森病患者的步速明显减慢,与姿势不稳定性和步态障碍评分呈显著负相关。网络连通性分析显示,与高危人群相比,帕金森氏症患者的视觉网络(VN)和小脑网络(CN)内网络功能连通性(FC)降低,但CN与感觉运动网络(SMN)和顶额叶网络(FPN)之间的网络功能连通性(FC)增加。步速缓慢的帕金森氏症亚组显示,SMN和VN内部网络FC增加,而VN与FPN和默认模式网络之间的FC减少。相关性分析表明,步速与CN的FC呈负相关,与CN-SMN的FC呈正相关。我们的研究确定了步速与临床特征之间的关系,以及帕金森病患者相应的网络连接改变,为了解帕金森病步态障碍的神经机制提供了见解。
{"title":"Altered gait speed and brain network connectivity in Parkinson's disease.","authors":"Shichan Wang, Yi Xiao, Yanbing Hou, Chunyu Li, Junyu Lin, Tianmi Yang, Ningning Che, Qirui Jiang, Xiaoting Zheng, Jiyong Liu, Huifang Shang","doi":"10.1093/cercor/bhae429","DOIUrl":"https://doi.org/10.1093/cercor/bhae429","url":null,"abstract":"<p><p>Slow gait speed and disrupted brain network connectivity are common in patients with Parkinson's disease (PD). This study aimed to clarify the relationship between gait speed and clinical characteristics in PD, and explore the underlying brain network mechanisms. Forty-two PD patients and 20 healthy controls (HC) were recruited. Statistical independent component analysis and correlation analysis were employed to investigate underlying neural mechanisms and relationships. PD patients exhibited significantly slower gait speed, which showed a significant negative correlation with postural instability and gait disturbance scores. Network connectivity analysis revealed decreased intranetwork functional connectivity (FC) within visual network (VN) and cerebellum network (CN), but increased internetwork FC between CN and both sensorimotor network (SMN) and frontoparietal network (FPN) in PD patients compared to HC. The slow gait speed PD subgroup demonstrated increased intranetwork FC within SMN and VN, along with decreased FC between VN and both FPN and default mode network. Correlation analyses revealed negative correlation between gait speed and FC of CN and positive correlation to FC of CN-SMN. Our study identified relationships between gait speed and clinical characteristics, and corresponding network connectivity alterations in PD patients, providing insights into the neural mechanisms underlying gait impairments in PD.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in resting-state functional connectivity of large-scale brain networks in bulimia nervosa: evidence from causal analysis. 神经性贪食症患者大规模大脑网络静息态功能连接的变化:因果分析的证据。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae430
Jiani Wang, Xinghao Wang, Yiling Wang, Weihua Li, Zhanjiang Li, Lirong Tang, Xinyu Huang, Marcin Grzegorzek, Qian Chen, Zhenchang Wang, Peng Zhang

Bulimia nervosa (BN) has been observationally linked to the functional connectivity (FC) of large-scale brain networks, but the biological mechanisms remain unclear. This study used two-sample Mendelian randomization (MR) with genetic variations as instrumental variables (IVs) to explore potential causal relationships between FC and BN. Summary data from genome-wide association studies (GWAS) involving 2,564 individuals were analyzed to identify genetically predicted BN. Functional magnetic resonance imaging parameters and materials were sourced from the UK Biobank. The variables underwent independent component analysis processing by the database to generate the final GWAS dataset. Various methods, including MR Pleiotropy RESidual Sum and Outlier, MR Egger, and weighted median, were employed to detect heterogeneity and pleiotropy, with inverse variance weighting serving as the principal estimation method (P < 0.05). The FC imaging-derived phenotypes revealed that BN exerted a causal influence on the FC between large-scale networks, including the visual network, default mode network (DMN), frontoparietal network, somatosensory network (SSN), and ventral attention network. Additionally, BN had a causal impact on the within-network FC of both the DMN and SSN. The study provides evidence that BN leads to further changes in FC patterns within and between large-scale brain networks.

据观察,神经性贪食症(BN)与大规模大脑网络的功能连通性(FC)有关,但其生物学机制仍不清楚。本研究采用双样本孟德尔随机化(MR)方法,以遗传变异作为工具变量(IV),探讨 FC 与 BN 之间的潜在因果关系。研究分析了涉及 2,564 人的全基因组关联研究(GWAS)的汇总数据,以确定遗传预测的 BN。功能磁共振成像参数和材料来自英国生物库。数据库对这些变量进行了独立成分分析处理,以生成最终的 GWAS 数据集。采用了多种方法检测异质性和多向性,包括 MR Pleiotropy RESidual Sum and Outlier、MR Egger 和加权中位数,并以反方差加权作为主要估计方法(P
{"title":"Changes in resting-state functional connectivity of large-scale brain networks in bulimia nervosa: evidence from causal analysis.","authors":"Jiani Wang, Xinghao Wang, Yiling Wang, Weihua Li, Zhanjiang Li, Lirong Tang, Xinyu Huang, Marcin Grzegorzek, Qian Chen, Zhenchang Wang, Peng Zhang","doi":"10.1093/cercor/bhae430","DOIUrl":"https://doi.org/10.1093/cercor/bhae430","url":null,"abstract":"<p><p>Bulimia nervosa (BN) has been observationally linked to the functional connectivity (FC) of large-scale brain networks, but the biological mechanisms remain unclear. This study used two-sample Mendelian randomization (MR) with genetic variations as instrumental variables (IVs) to explore potential causal relationships between FC and BN. Summary data from genome-wide association studies (GWAS) involving 2,564 individuals were analyzed to identify genetically predicted BN. Functional magnetic resonance imaging parameters and materials were sourced from the UK Biobank. The variables underwent independent component analysis processing by the database to generate the final GWAS dataset. Various methods, including MR Pleiotropy RESidual Sum and Outlier, MR Egger, and weighted median, were employed to detect heterogeneity and pleiotropy, with inverse variance weighting serving as the principal estimation method (P < 0.05). The FC imaging-derived phenotypes revealed that BN exerted a causal influence on the FC between large-scale networks, including the visual network, default mode network (DMN), frontoparietal network, somatosensory network (SSN), and ventral attention network. Additionally, BN had a causal impact on the within-network FC of both the DMN and SSN. The study provides evidence that BN leads to further changes in FC patterns within and between large-scale brain networks.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurophysiological evidence of motor contribution to vicarious affective touch. 神经生理学证据表明,运动有助于产生代入式情感触觉。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae441
Niccolò Butti, Cosimo Urgesi, Stergios Makris, Francis P McGlone, Rosario Montirosso, Valentina Cazzato

Understanding observed interpersonal touch, particularly the so-called affective touch targeting the CT fibers, is essential for social interactions. Research has documented that observing other people being touched activates the same cortical areas involved in direct tactile experiences. However, observing interpersonal touch also activates an inner simulation of the movements in the observer's motor system. Given the social and affective significance of CT-optimal touch, the present study tested the hypothesis that observing stroking touches targeting or not targeting the CT fibers system might distinctly influence motor resonance to vicarious touch. With this aim, we used single-pulse transcranial magnetic stimulation and motor-evoked potentials recording while participants observed video clips of interpersonal touch events at different stroking velocities. We found a modulation of motor system activity, particularly a decrease in corticospinal excitability, when observing CT-optimal touch as opposed to non-CT-optimal velocities, a mechanism that might aid in understanding the touchee's feelings during vicarious interpersonal touch. Moreover, participants with higher reliance on bodily cues to be emotionally aware showed greater motor suppression for CT-optimal compared to non-CT-optimal velocities. These results shed light on the complex interplay between motor and somatosensory systems in social touch perception and emphasize the importance of affective touch in human social interactions.

了解观察到的人际触觉,尤其是以 CT 纤维为目标的所谓情感触觉,对于社会交往至关重要。研究表明,观察他人被触摸会激活与直接触觉体验相关的皮层区域。然而,观察人与人之间的触摸也会激活观察者运动系统对动作的内在模拟。鉴于 CT 最佳触觉的社会和情感意义,本研究测试了这样一个假设:观察以 CT 纤维系统为目标或不以 CT 纤维系统为目标的抚摸可能会明显影响对替代性触觉的运动共振。为此,我们使用了单脉冲经颅磁刺激和运动诱发电位记录,同时让参与者观察不同抚摸速度下的人际抚摸事件视频剪辑。我们发现,在观察 CT 最佳抚摸速度与非 CT 最佳抚摸速度时,运动系统的活动会受到调节,尤其是皮质脊髓兴奋性会降低,这种机制可能有助于理解被抚摸者在替代性人际抚摸过程中的感受。此外,与非 CT 最佳速度相比,更依赖身体线索来感知情感的参与者对 CT 最佳速度表现出更大的运动抑制。这些结果揭示了运动系统和体感系统在社交触觉感知中复杂的相互作用,并强调了情感触觉在人类社交互动中的重要性。
{"title":"Neurophysiological evidence of motor contribution to vicarious affective touch.","authors":"Niccolò Butti, Cosimo Urgesi, Stergios Makris, Francis P McGlone, Rosario Montirosso, Valentina Cazzato","doi":"10.1093/cercor/bhae441","DOIUrl":"10.1093/cercor/bhae441","url":null,"abstract":"<p><p>Understanding observed interpersonal touch, particularly the so-called affective touch targeting the CT fibers, is essential for social interactions. Research has documented that observing other people being touched activates the same cortical areas involved in direct tactile experiences. However, observing interpersonal touch also activates an inner simulation of the movements in the observer's motor system. Given the social and affective significance of CT-optimal touch, the present study tested the hypothesis that observing stroking touches targeting or not targeting the CT fibers system might distinctly influence motor resonance to vicarious touch. With this aim, we used single-pulse transcranial magnetic stimulation and motor-evoked potentials recording while participants observed video clips of interpersonal touch events at different stroking velocities. We found a modulation of motor system activity, particularly a decrease in corticospinal excitability, when observing CT-optimal touch as opposed to non-CT-optimal velocities, a mechanism that might aid in understanding the touchee's feelings during vicarious interpersonal touch. Moreover, participants with higher reliance on bodily cues to be emotionally aware showed greater motor suppression for CT-optimal compared to non-CT-optimal velocities. These results shed light on the complex interplay between motor and somatosensory systems in social touch perception and emphasize the importance of affective touch in human social interactions.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurophysiological characteristics of reward processing in individuals at different levels of gaming. 不同游戏水平的个体奖励处理的神经生理学特征。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae436
Yanjie Peng, DanTong Wu, Mingyuan Tian, Yanyin Zhou, Xiaohong Peng, Zhenlei Peng, Ke Gong, Kezhi Liu, Jing Chen, Wei Lei

Altered reward processing has been repeatedly reported in Internet gaming disorder (IGD). However, it remains unclear whether these changes are linked to the severity of addictive symptoms or the extent of gaming experience. This study examined the neurophysiological responses regarding reward anticipation and consummation in individuals at different levels of gaming (including 22 casual gamers, 31 regular gamers, and 27 individuals with IGD) through a monetary incentive delay task. Three event-related potential components during reward anticipation-cue-related P300 (Cue-P3), contingent negative variation, and stimulus-preceding negativity (SPN)-and two during reward consummation-feedback-related negativity and feedback-related P300 (FB-P3)-were measured. We found that IGD individuals exhibited greater Cue-P3 but lower SPN amplitude compared to casual gamers, while regular gamers fell between the two without significant differences. Regressions indicated that more extensive gaming experience, rather than the severity of the symptoms, primarily contributed to the increased Cue-P3 in IGD. No group differences were found during reward consummation. Our results highlight disrupted reward anticipation processing in IGD, characterized by increased attention bias toward reward cues (Cue-P3) but diminished cognitive resources for reward anticipation (SPN) and emphasize the role of gaming experience in increased attention bias in IGD.

网络游戏障碍(IGD)患者的奖赏加工过程发生改变的报道屡见不鲜。然而,这些变化是否与成瘾症状的严重程度或游戏经验的丰富程度有关,目前仍不清楚。本研究通过货币激励延迟任务,研究了不同游戏水平的个体(包括 22 名休闲游戏玩家、31 名普通游戏玩家和 27 名 IGD 患者)在奖励预期和消耗方面的神经生理反应。我们测量了奖励预期过程中的三个事件相关电位成分--线索相关 P300 (Cue-P3)、或有负变异和刺激前负性 (SPN),以及奖励消耗过程中的两个事件相关电位成分--反馈相关负性和反馈相关 P300 (FB-P3)。我们发现,与休闲游戏玩家相比,IGD 表现出更高的 Cue-P3 和更低的 SPN 振幅,而普通游戏玩家则介于两者之间,没有显著差异。回归结果表明,更丰富的游戏经验,而不是症状的严重程度,是导致 IGD Cue-P3 增加的主要原因。在奖赏消耗过程中,没有发现组间差异。我们的研究结果表明,IGD 的奖赏预期处理过程受到了干扰,其特点是对奖赏线索(Cue-P3)的注意偏向增加,而对奖赏预期(SPN)的认知资源却减少,并强调了游戏经历在 IGD 注意偏向增加中的作用。
{"title":"Neurophysiological characteristics of reward processing in individuals at different levels of gaming.","authors":"Yanjie Peng, DanTong Wu, Mingyuan Tian, Yanyin Zhou, Xiaohong Peng, Zhenlei Peng, Ke Gong, Kezhi Liu, Jing Chen, Wei Lei","doi":"10.1093/cercor/bhae436","DOIUrl":"https://doi.org/10.1093/cercor/bhae436","url":null,"abstract":"<p><p>Altered reward processing has been repeatedly reported in Internet gaming disorder (IGD). However, it remains unclear whether these changes are linked to the severity of addictive symptoms or the extent of gaming experience. This study examined the neurophysiological responses regarding reward anticipation and consummation in individuals at different levels of gaming (including 22 casual gamers, 31 regular gamers, and 27 individuals with IGD) through a monetary incentive delay task. Three event-related potential components during reward anticipation-cue-related P300 (Cue-P3), contingent negative variation, and stimulus-preceding negativity (SPN)-and two during reward consummation-feedback-related negativity and feedback-related P300 (FB-P3)-were measured. We found that IGD individuals exhibited greater Cue-P3 but lower SPN amplitude compared to casual gamers, while regular gamers fell between the two without significant differences. Regressions indicated that more extensive gaming experience, rather than the severity of the symptoms, primarily contributed to the increased Cue-P3 in IGD. No group differences were found during reward consummation. Our results highlight disrupted reward anticipation processing in IGD, characterized by increased attention bias toward reward cues (Cue-P3) but diminished cognitive resources for reward anticipation (SPN) and emphasize the role of gaming experience in increased attention bias in IGD.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis. 主观耳鸣的神经解剖相关性:高级皮层形态分析的启示。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae432
Himanshu R Pandey, Amit Keshri, Neeraj Sinha, Uttam Kumar

Subjective tinnitus, characterized by the perception of phantom sounds in the absence of external stimuli, presents significant challenges in both audiology and neurology. Once thought to primarily involve aberrant neural activity within auditory pathways, it is now understood to engage a broader array of neuroanatomical structures. This study investigated the connections between auditory, cognitive, and sensory processing regions, which are crucial for unraveling the complex neurobiological basis of tinnitus. Using high-resolution T1-weighted magnetic resonance imaging, we compared 52 individuals with subjective tinnitus with 52 age-matched healthy controls, focusing on cerebral cortex features, including fractal dimensionality, gyrification, and sulcal depth. Covariate analyses were conducted to explore the relationships between tinnitus duration, Tinnitus Handicap Inventory scores, anxiety score, and neuroanatomical changes. We found significant alterations in key brain regions involved in sensory processing, cognition, and emotional regulation, including the insula, lateral occipital cortex, middle frontal gyrus, and superior parietal lobule. These neuroanatomical changes were strongly correlated with the severity and chronicity of tinnitus symptoms. Our findings reveal profound structural changes in the brain associated with subjective tinnitus, offering valuable insights into the condition's underlying mechanisms and providing a potential framework for guiding future research and therapeutic interventions.

主观性耳鸣的特点是在没有外部刺激的情况下感觉到幻听,这给听力学和神经学带来了重大挑战。人们曾一度认为耳鸣主要涉及听觉通路中的异常神经活动,而现在则认为耳鸣涉及更广泛的神经解剖结构。本研究调查了听觉、认知和感觉处理区域之间的联系,这对于揭示耳鸣复杂的神经生物学基础至关重要。通过使用高分辨率 T1 加权磁共振成像,我们比较了 52 名主观性耳鸣患者和 52 名年龄匹配的健康对照者,重点研究了大脑皮层的特征,包括分形维度、回化率和沟深度。我们进行了协变量分析,以探讨耳鸣持续时间、耳鸣障碍量表评分、焦虑评分和神经解剖变化之间的关系。我们发现,涉及感觉处理、认知和情绪调节的主要脑区,包括岛叶、枕叶外侧皮层、额叶中回和顶叶上小叶都发生了明显变化。这些神经解剖学变化与耳鸣症状的严重程度和慢性化程度密切相关。我们的研究结果揭示了与主观性耳鸣相关的大脑结构的深刻变化,为了解耳鸣的内在机制提供了宝贵的见解,并为指导未来的研究和治疗干预提供了潜在的框架。
{"title":"Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis.","authors":"Himanshu R Pandey, Amit Keshri, Neeraj Sinha, Uttam Kumar","doi":"10.1093/cercor/bhae432","DOIUrl":"https://doi.org/10.1093/cercor/bhae432","url":null,"abstract":"<p><p>Subjective tinnitus, characterized by the perception of phantom sounds in the absence of external stimuli, presents significant challenges in both audiology and neurology. Once thought to primarily involve aberrant neural activity within auditory pathways, it is now understood to engage a broader array of neuroanatomical structures. This study investigated the connections between auditory, cognitive, and sensory processing regions, which are crucial for unraveling the complex neurobiological basis of tinnitus. Using high-resolution T1-weighted magnetic resonance imaging, we compared 52 individuals with subjective tinnitus with 52 age-matched healthy controls, focusing on cerebral cortex features, including fractal dimensionality, gyrification, and sulcal depth. Covariate analyses were conducted to explore the relationships between tinnitus duration, Tinnitus Handicap Inventory scores, anxiety score, and neuroanatomical changes. We found significant alterations in key brain regions involved in sensory processing, cognition, and emotional regulation, including the insula, lateral occipital cortex, middle frontal gyrus, and superior parietal lobule. These neuroanatomical changes were strongly correlated with the severity and chronicity of tinnitus symptoms. Our findings reveal profound structural changes in the brain associated with subjective tinnitus, offering valuable insights into the condition's underlying mechanisms and providing a potential framework for guiding future research and therapeutic interventions.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing perceptual, attentional, and working memory demands through variable practice schedules: insights from high-density EEG multi-scale analyses. 通过不同的练习时间表提高知觉、注意力和工作记忆要求:高密度脑电图多尺度分析的启示。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae425
Alexandre Cretton, Kate Schipper, Mahmoud Hassan, Paolo Ruggeri, Jérôme Barral

Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than a blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits that better learning is due to highly activated mnemonic processes. We used high-density electroencephalography in a multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, to examine the intertwined dynamics of attentional and mnemonic processes within short time windows. We recorded scalp activity from 35 participants as they performed an aiming task at three different distances, under both random and blocked conditions using a crossover design. Our results showed that topographies associated with processes related to perception/attention (N1, P3a) and working memory (P3b) were more pronounced in the random condition. Source estimation analyses supported these findings, revealing greater involvement of the perceptual ventral pathway, anterior cingulate and parietal cortices, along with increased functional connectivity in ventral alpha and frontoparietal theta band networks during random practice. Our results suggest that CI is driven, in the random compared to the blocked condition, by enhanced specific processes such as perceptual, attentional, and working memory processes, as well as large-scale functional networks sustaining more general attentional and executive processes.

情境干扰(Contextual interference,CI)可通过以随机顺序而非阻塞顺序练习运动任务来提高学习效果。一种假说认为,这种益处来自于早期知觉/注意过程的增强,而另一种假说则认为,更好的学习是由于记忆过程的高度激活。我们使用高密度脑电图进行多尺度分析,包括地形分析、源估计和功能连接,以研究短时间窗口内注意力和记忆过程相互交织的动态变化。我们采用交叉设计,在随机和阻断条件下记录了 35 名参与者在三个不同距离执行瞄准任务时的头皮活动。我们的结果表明,在随机条件下,与感知/注意力(N1、P3a)和工作记忆(P3b)相关过程有关的拓扑结构更为明显。源估计分析支持了这些发现,揭示了在随机练习过程中,知觉腹侧通路、前扣带回和顶叶皮层的参与程度更高,同时腹侧阿尔法和前顶叶θ波段网络的功能连接也有所增加。我们的研究结果表明,与阻断条件相比,在随机条件下,知觉、注意和工作记忆过程等特定过程以及维持更普遍的注意和执行过程的大规模功能网络都得到了增强。
{"title":"Enhancing perceptual, attentional, and working memory demands through variable practice schedules: insights from high-density EEG multi-scale analyses.","authors":"Alexandre Cretton, Kate Schipper, Mahmoud Hassan, Paolo Ruggeri, Jérôme Barral","doi":"10.1093/cercor/bhae425","DOIUrl":"10.1093/cercor/bhae425","url":null,"abstract":"<p><p>Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than a blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits that better learning is due to highly activated mnemonic processes. We used high-density electroencephalography in a multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, to examine the intertwined dynamics of attentional and mnemonic processes within short time windows. We recorded scalp activity from 35 participants as they performed an aiming task at three different distances, under both random and blocked conditions using a crossover design. Our results showed that topographies associated with processes related to perception/attention (N1, P3a) and working memory (P3b) were more pronounced in the random condition. Source estimation analyses supported these findings, revealing greater involvement of the perceptual ventral pathway, anterior cingulate and parietal cortices, along with increased functional connectivity in ventral alpha and frontoparietal theta band networks during random practice. Our results suggest that CI is driven, in the random compared to the blocked condition, by enhanced specific processes such as perceptual, attentional, and working memory processes, as well as large-scale functional networks sustaining more general attentional and executive processes.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience. 扩展勒杜的见解:利用电影研究神经科学中具有临床意义的主观体验。
IF 2.9 2区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-18 DOI: 10.1093/cercor/bhae422
Peter A Kirk, Daniel S Pine, Katharina Kircanski

Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.

与情绪失调的公共卫生相关的神经科学研究探讨了大脑与行为之间的关系。乔-勒杜的遗产以真正独特的方式推动着这些工作。虽然他的基础科学研究得到了认可,但他也激励着应用研究人员,为临床科学家指引了一项议程:了解情绪障碍中主观体验改变的病理生理学。在脑成像方面,由于电影在唤起丰富、有意义的主观体验方面具有相对优势,因此观看电影的方法有助于临床医生实现这一议程。在此,我们将介绍观影范式在方法论上的进步,这些进步可能会通过促进发现产生复杂情绪反应的神经机制来保持勒杜的影响力。值得注意的是,虽然将主观情绪与病理生理学联系起来是第一步,但观影设计的创新,尤其是涉及情绪障碍治疗技术的创新,可以促进临床应用。利用病理生理学研究产生新的治疗方法,体现了乔-勒杜令人振奋的职业生涯所带来的临床遗产。
{"title":"Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.","authors":"Peter A Kirk, Daniel S Pine, Katharina Kircanski","doi":"10.1093/cercor/bhae422","DOIUrl":"https://doi.org/10.1093/cercor/bhae422","url":null,"abstract":"<p><p>Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Cerebral cortex
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1