tDCS and local scalp cooling do not change corticomotor and intracortical excitability in healthy humans

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-09-28 DOI:10.1016/j.clinph.2024.09.023

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Abstract

Objective

Scalp cooling might increase the long-term potentiation (LTP)-like effect of transcranial direct current stimulation (tDCS) by reducing the threshold for after-effects according to metaplasticity and increasing electrical current density reaching the cortical neurons. We aimed to investigate whether priming scalp cooling potentiates the tDCS after-effect on motor cortex excitability.

Methods

This study had a randomized, parallel-arms, sham-controlled, double-blinded design with an adequately powered sample of 105 healthy subjects. Corticomotor and intracortical excitability were assessed with motor evoked potentials (MEP) from transcranial magnetic stimulation (TMS) in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) paradigms. Subjects were randomly allocated into six intervention groups, including anodal and cathodal tDCS (1-mA/20-min), scalp cooling, and sham. MEPs were recorded before, immediately, and 15 min after the interventions.

Results

We did not observe changes in MEP amplitude from single-pulse TMS, SICI, and ICF with any intervention protocol.

Conclusion

Anodal and cathodal tDCS did not have an LTP-like neuromodulatory effect on corticospinal and did not provide detectable GABAergic and glutamatergic neurotransmission changes, which were not influenced by priming scalp cooling.

Significance

We provide strong evidence that tDCS (1-mA/20-min) does not alter corticomotor and intracortical excitability with or without priming scalp cooling.

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tDCS 和局部头皮冷却不会改变健康人的皮质运动和皮质内兴奋性。

目的头皮冷却可能会提高经颅直流电刺激（tDCS）的长期电位（LTP）样效应，其方法是根据元弹性降低后效应阈值并增加到达皮层神经元的电流密度。我们的目的是研究头皮冷却是否会增强 tDCS 对运动皮层兴奋性的后效应：本研究采用随机、平行臂、假对照、双盲设计，对 105 名健康受试者进行了充分的抽样调查。在短间隔皮层内抑制（SICI）和皮层内促进（ICF）范例中，通过经颅磁刺激（TMS）产生的运动诱发电位（MEP）评估皮层运动和皮层内兴奋性。受试者被随机分配到六个干预组，包括阳极和阴极 tDCS（1-mA/20-min）、头皮冷却和假干预。分别在干预前、干预后和干预后 15 分钟记录 MEPs：结果：在任何干预方案下，我们都没有观察到单脉冲 TMS、SICI 和 ICF 对 MEP 振幅的影响：结论：正极和负极 tDCS 对皮质脊髓没有 LTP 样的神经调节作用，也没有提供可检测到的 GABA 能和谷氨酸能神经传递变化，这些变化不受引物头皮冷却的影响：我们提供了强有力的证据，证明无论是否使用头皮冷却引物，tDCS（1-mA/20-min）都不会改变皮质运动和皮质内的兴奋性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.