Breast Cancer and Risk of Depression: A Comparative Cross-Sectional Study Among Women With and Without Breast Cancer in Addis Ababa, Ethiopia.

IF 3.2 Q2 ONCOLOGY JCO Global Oncology Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI:10.1200/GO.24.00235
Alem Gebremariam, Adamu Addissie, Nebiyu Dereje, Mathewos Assefa, Ahmedin Jemal
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Abstract

Purpose: The extent of symptoms of depression among patients with breast cancer compared with those without the disease is not well documented in Ethiopia and other sub-Saharan African countries.

Materials and methods: This study examines the prevalence of symptoms of depression in women with breast cancer (n = 436) compared with those without breast cancer (n = 856) in Addis Ababa, Ethiopia, through a comparative cross-sectional study using a validated questionnaire, the Patient Health Questionnaire-9. The association between breast cancer diagnosis and symptoms of depression was evaluated using a multivariable binary logistic regression model.

Results: About 39.2% of women with breast cancer had some level of symptoms of depression compared with 23.8% of women without the disease. By severity of symptoms of depression, 13.1% of women with breast cancer reported moderate to severe symptoms of depression compared with 6.8% of women without the disease. Sixty-three percent of women with breast cancer reported difficulties performing routine daily activities, compared with 36.7% of women without the disease. In the multivariable-adjusted model, women with breast cancer were 2 times (adjusted odds ratio, 2.26 [95% CI, 1.49 to 3.44]) more likely to report symptoms of depression compared with those without the disease. Likewise, women with breast cancer were 4.78 (95% CI, 3.51 to 6.52) times more likely to report difficulty in performing routine daily activities compared with women without the disease.

Conclusion: Four in 10 women with breast cancer in Addis Ababa reported having symptoms of depression, which was considerably higher than women in the general population. This finding emphasizes the importance of addressing psychosocial needs among women with breast cancer to enhance quality of life and potentially extend longevity.

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乳腺癌与抑郁风险:埃塞俄比亚亚的斯亚贝巴患乳腺癌和未患乳腺癌妇女的横断面比较研究》(A Comparative Cross-Sectional Study Among Women With and Without Breast Cancer in Addis Ababa, Ethiopia.
目的:在埃塞俄比亚和其他撒哈拉以南非洲国家,与未患乳腺癌的患者相比,乳腺癌患者抑郁症状的程度并没有得到很好的记录:本研究通过一项横断面比较研究,使用经过验证的问卷--患者健康问卷-9,对埃塞俄比亚亚的斯亚贝巴的乳腺癌女性患者(n = 436)与非乳腺癌女性患者(n = 856)的抑郁症状发生率进行了调查。使用多变量二元逻辑回归模型评估了乳腺癌诊断与抑郁症状之间的关系:结果:约 39.2% 的乳腺癌妇女有一定程度的抑郁症状,而未患乳腺癌的妇女只有 23.8%。从抑郁症状的严重程度来看,13.1%的乳腺癌妇女报告有中度至重度抑郁症状,而未患乳腺癌的妇女仅为6.8%。63%的乳腺癌妇女在进行日常活动时遇到困难,而未患乳腺癌的妇女中这一比例为36.7%。在多变量调整模型中,与未患乳腺癌的妇女相比,患乳腺癌的妇女报告抑郁症状的几率要高出2倍(调整后的几率比为2.26 [95% CI,1.49至3.44])。同样,与未患乳腺癌的妇女相比,患乳腺癌的妇女在进行日常活动时遇到困难的几率是未患乳腺癌妇女的 4.78 倍(95% CI,3.51 至 6.52):在亚的斯亚贝巴,每 10 名乳腺癌妇女中就有 4 人报告有抑郁症状,大大高于普通妇女。这一发现强调了解决乳腺癌妇女的社会心理需求以提高生活质量和延长寿命的重要性。
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来源期刊
JCO Global Oncology
JCO Global Oncology Medicine-Oncology
CiteScore
6.70
自引率
6.70%
发文量
310
审稿时长
7 weeks
期刊最新文献
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