Ethnic-Specific Threshold Analysis and BMI and Waist Circumference Cutoffs for Cardiovascular Disease and Subjective Wellbeing: Results using Data from the UK Biobank.
Mubarak Patel, Mohammed Aadil Buchya, Olalekan Uthman
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引用次数: 0
Abstract
Objectives: We aimed to identify ethnicity-specific BMI and waist circumference cutoffs for cardiovascular disease (CVD) and to define optimal thresholds for CVD risk and subjective wellbeing (SWB) through predictive modelling, to inform precise public health initiatives.
Methods: We used data from 296,767 UK Biobank participants and adjusted logistic and linear regression models for CVD and SWB, respectively, complemented by receiver operating characteristic analysis, to explore optimal risk thresholds of CVD in six different ethnic groups and to calculate ethnicity-specific cutoffs of BMI and waist circumference (WC) to further elucidate the relationships between demographic factors and cardiovascular risk among diverse populations.
Results: The logistic regression model of CVD revealed moderate discriminative ability (AUROC ~ 64-65%) across ethnicities for CVD status, with sensitivity and specificity values indicating the model's predictive accuracy. For SWB, the model demonstrated moderate performance with an AUROC of 63%, supported by significant variables that included age, BMI, WC, physical activity, and alcohol intake. Adjusted-incidence rates of CVD revealed the evidence ethnic-specific CVD risk profiles with Whites, South Asians and Blacks demonstrating higher predicted CVD events compared to East Asians, mixed and other ethnic groups.
Conclusion: Alterations of ethnicity-specific BMI and waist circumference are required to ensure ethnic minorities are provided with proper mitigation of cardiovascular risk, addressing the disparities observed in CVD prevalence and outcomes across diverse populations. This tailored approach to risk assessment can facilitate early detection, intervention and management of CVD, ultimately improving health outcomes and promoting health equity. The moderate accuracy of predictive models underscores the need for further research to identify additional variables that may enhance predictive accuracy and refine risk assessment strategies.
期刊介绍:
Journal of Racial and Ethnic Health Disparities reports on the scholarly progress of work to understand, address, and ultimately eliminate health disparities based on race and ethnicity. Efforts to explore underlying causes of health disparities and to describe interventions that have been undertaken to address racial and ethnic health disparities are featured. Promising studies that are ongoing or studies that have longer term data are welcome, as are studies that serve as lessons for best practices in eliminating health disparities. Original research, systematic reviews, and commentaries presenting the state-of-the-art thinking on problems centered on health disparities will be considered for publication. We particularly encourage review articles that generate innovative and testable ideas, and constructive discussions and/or critiques of health disparities.Because the Journal of Racial and Ethnic Health Disparities receives a large number of submissions, about 30% of submissions to the Journal are sent out for full peer review.