{"title":"The <i>Caenorhabditis elegans</i> Dispatched ortholog, CHE-14, is dispensable for apical secretion of the Hedgehog-related proteins GRL-2 and WRT-10.","authors":"Nicholas D Serra, Meera V Sundaram","doi":"10.17912/micropub.biology.001329","DOIUrl":null,"url":null,"abstract":"<p><p><i>C. elegans</i> nematodes possess expanded families of Hedgehog related (Hh-r) and Patched/Dispatched-related (PTR) proteins but their functional relationship remains unclear. Here we investigated whether CHE-14 , the closest <i>C. elegans</i> ortholog for the Hedgehog transporter Dispatched, was necessary for the secretion of two tagged Hh-r proteins: WRT-10 and GRL-2 . We report that CHE-14 is dispensable for the apical localization of GRL-2 and WRT-10 . We also show that animals lacking CHE-14 and another redundant PTR protein DAF-6 also secrete WRT-10 , suggesting neither are required for secretion of these specific Hh-r proteins.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465080/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001329","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
C. elegans nematodes possess expanded families of Hedgehog related (Hh-r) and Patched/Dispatched-related (PTR) proteins but their functional relationship remains unclear. Here we investigated whether CHE-14 , the closest C. elegans ortholog for the Hedgehog transporter Dispatched, was necessary for the secretion of two tagged Hh-r proteins: WRT-10 and GRL-2 . We report that CHE-14 is dispensable for the apical localization of GRL-2 and WRT-10 . We also show that animals lacking CHE-14 and another redundant PTR protein DAF-6 also secrete WRT-10 , suggesting neither are required for secretion of these specific Hh-r proteins.
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