A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report.

IF 0.6 Q4 ONCOLOGY Case Reports in Oncological Medicine Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.1155/2024/9340657
Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed
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Abstract

Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely.

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治疗局部晚期鼻窦癌的新型分次高剂量姑息放疗方案:病例报告。
鼻窦恶性肿瘤(SNMs)是一种罕见的异质性恶性肿瘤,常表现为局部晚期疾病。如果病变范围广且无法切除,预后较差。在这种情况下,通常需要采用大剂量姑息性放疗方案,但理想的剂量和分次放疗方案尚未确定。我们详细介绍了一名 33 岁男性的病例,他最初表现为右脸颊上逐渐增大的肿块。病变活检显示为鳞状细胞癌(SCC)。影像学检查显示该病已发展到晚期,无法切除,并累及多个头颈部亚部位。在接受外部机构的诱导化疗后,病情进一步恶化。患者要求尽快控制肿瘤和症状,以便回国治疗。我们为他提供了大剂量分次姑息放疗,即每天两次,每次四发,每次四分,每次14.80Gy,然后隔天一次,每次五发,每次30Gy,间隔2周。治疗取得了很好的临床效果,症状在短时间内得到缓解,患者可以安全回家。
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来源期刊
自引率
0.00%
发文量
11
审稿时长
16 weeks
期刊介绍: Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.
期刊最新文献
A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report. Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review. Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma. Diagnosis and Management of a Patient With Chronic Lymphocytic Leukemia and a Concurrent Plasmacytoma. A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer.
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