Carbon-Based Biosensor in Point of Care Setting

Jiaqi Jin, Jiuchuan Guo, Jinhong Guo, Diangeng Li
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Abstract

In medical diagnosis, detecting disease biomarkers at ultra-low concentrations is vital. Point-of-care (POC) diagnostics require rapid detection, live monitoring, high sensitivity, low detection threshold, and cost-effectiveness. Carbon-based nanomaterials (CBNs) are promising due to their large surface-to-volume ratio, conductivity, biocompatibility, and stability, making them ideal for biosensors. Recent advancements in CBN applications, including biosensing, drug delivery, and cancer therapy, highlight their potential in enhancing detection sensitivity and specificity. Electrochemical sensors and biosensor platforms using carbon nanocomposites are pivotal in diagnostics. This review explores the current state and future challenges of CBN integration in POC settings, envisioning a transformative impact on healthcare diagnostics and therapeutics.

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医疗点中的碳基生物传感器
在医疗诊断中,检测超低浓度的疾病生物标志物至关重要。床旁(POC)诊断需要快速检测、实时监测、高灵敏度、低检测阈值和成本效益。碳基纳米材料(CBN)因其巨大的表面体积比、导电性、生物相容性和稳定性而前景广阔,是生物传感器的理想选择。CBN 应用领域的最新进展,包括生物传感、药物输送和癌症治疗,凸显了它们在提高检测灵敏度和特异性方面的潜力。使用碳纳米复合材料的电化学传感器和生物传感器平台在诊断中举足轻重。本综述探讨了将 CBN 集成到 POC 设置中的现状和未来挑战,并展望了其对医疗诊断和治疗的变革性影响。
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