Development of 3D printed microneedles of varied needle geometries and lengths, designed to improve the dermal delivery of topically applied psoriasis treatments

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2024-10-10 DOI:10.1016/j.ejpb.2024.114523

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Abstract

The aim of this study was to investigate the impact of using microneedle patches in addition to topical therapy for the treatment of psoriasis. Using continuous liquid interface production (CLIP) 3D printing we manufactured round microneedle array patches (MAPs) with a diameter of 14 mm. Needle geometries were varied from square pyramidal, conical, and obelisk, with varied needle lengths of 400 µm, 600 µm, 800 µm, or 1000 µm. MAPs were characterized for force to fracture, skin penetration, skin damage, as well as their ability to deliver a novel oleogel-based corticosteroid (betamethasone dipropionate (BDP) formulation into ex-vivo porcine skin. We found that the obelisk shaped MAPs are more durable compared to the conical and square pyramidal-shaped MAPs. When the obelisk shaped MAPs were used in combination with the oleogel-based BDP formulation, the amount of BDP penetrating the skin was significantly increased with greater needle lengths.

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开发具有不同针头几何形状和长度的 3D 打印微针，旨在改善局部牛皮癣治疗的皮肤给药。

本研究旨在探讨在局部治疗的基础上使用微针贴片对银屑病治疗的影响。我们使用连续液体界面生产（CLIP）3D 打印技术制造了直径为 14 毫米的圆形微针阵列贴片（MAPs）。针的几何形状有方形、锥形和方尖形，针的长度有 400 微米、600 微米、800 微米或 1000 微米。我们对 MAP 的断裂力、皮肤穿透力、皮肤损伤以及将新型油凝胶皮质类固醇（二丙酸倍他米松（BDP）制剂）输送到活体猪皮肤的能力进行了表征。我们发现，与锥形和方形金字塔形的 MAP 相比，方尖碑形的 MAP 更为耐用。当方尖碑形 MAP 与油凝胶型 BDP 制剂结合使用时，随着针头长度的增加，BDP 穿透皮肤的量也显著增加。

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来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.