Epidemiology and treatment of herpes simplex virus in the neonatal intensive care unit

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-10-11 DOI:10.1038/s41372-024-02150-8

Nellie Chen, Ryan Kilpatrick, Erik J. VerHage, P. Brian Smith, Areej Bukhari, Chi D. Hornik, Veeral N. Tolia, Daniel K. Benjamin Jr, Rachel G. Greenberg

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Abstract

Describe the epidemiology and clinical characteristics of infants in the neonatal intensive care unit (NICU) with acyclovir exposure and herpes simplex virus (HSV) infection. Our primary analysis was to evaluate the prevalence of HSV infection among infants in the NICU who received acyclovir. We compared characteristics of infants with and without HSV and used multivariable regression analyses to assess associations between infection and clinical outcomes. Of 1,057,061 infants, 17,910 (2%) received acyclovir. Of those who received acyclovir, 1090 (5%) had HSV. Infection was associated with lower gestational age and lower birth weight. Multivariable models demonstrated that infected infants had higher mortality, greater postmenstrual age at discharge, and longer length of stay. Infants in the NICU who received acyclovir and have HSV are more likely to be born at lower gestational age, have lower birth weight, and have higher morbidities and mortality.

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新生儿重症监护室单纯疱疹病毒的流行病学和治疗。

目的：描述新生儿重症监护病房中接触阿昔洛韦并感染单纯疱疹病毒（HSV）的婴儿的流行病学和临床特征：描述新生儿重症监护病房（NICU）中暴露于阿昔洛韦的婴儿和单纯疱疹病毒（HSV）感染的流行病学和临床特征：我们的主要分析目的是评估新生儿重症监护室中接受过阿昔洛韦治疗的婴儿中 HSV 感染率。我们比较了感染和未感染 HSV 的婴儿的特征，并使用多变量回归分析评估感染与临床结果之间的关联：在 1,057,061 名婴儿中，17,910 名（2%）接受了阿昔洛韦治疗。在接受阿昔洛韦治疗的婴儿中，有 1090 人（5%）感染了 HSV。感染与较低的胎龄和较低的出生体重有关。多变量模型显示，受感染的婴儿死亡率更高，出院时月经后年龄更大，住院时间更长：结论：在新生儿重症监护病房接受阿昔洛韦治疗并感染 HSV 的婴儿更有可能在较低胎龄出生，出生体重较轻，发病率和死亡率较高。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.