Diverse molecular mechanisms underpinning Staphylococcus aureus small colony variants.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-10-10 DOI:10.1016/j.tim.2024.09.007
Maryam Mapar, Thomas Rydzak, Josefien W Hommes, Bas G J Surewaard, Ian A Lewis
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引用次数: 0

Abstract

Small colony variants (SCVs) of Staphylococcus aureus are a relatively rare but clinically significant growth morphotype. Infections with SCVs are frequently difficult to treat, inherently antibiotic-resistant, and can lead to persistent infections. Despite a long history of research, the molecular underpinnings of this morphotype and their impact on the clinical trajectory of infections remain unclear. However, a growing body of literature indicates that SCVs are caused by a diverse range of molecular factors. These recent findings suggest that SCVs should be thought of as an ensemble collection of loosely related phenotypes, and not as a single phenomenon. This review describes the diverse mechanisms currently known to contribute to SCVs and proposes an ensemble model for conceptualizing this morphotype.

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金黄色葡萄球菌小菌落变异的多种分子机制。
金黄色葡萄球菌的小菌落变异株(SCV)是一种相对罕见但具有临床意义的生长形态。SCVs 感染通常难以治疗,本身具有抗生素耐药性,并可能导致持续感染。尽管研究历史悠久,但这种形态的分子基础及其对感染临床轨迹的影响仍不清楚。然而,越来越多的文献表明,SCV 是由多种分子因素引起的。这些最新研究结果表明,SCV 应被视为一系列松散相关的表型,而非单一现象。这篇综述描述了目前已知的导致SCV的各种机制,并提出了一个集合模型来概念化这种形态。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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