Exploring stem cell technology: Pioneering new pathways for female fertility preservation and restoration

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-10-10 DOI:10.1016/j.repbio.2024.100958

Ningjing Li , Xinrong Du , Yuhong Zhao , Qin Zeng , Changli Han , Dongsheng Xiong , Libing He , Guohui Zhang , Weixin Liu

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Abstract

The fertility of women is crucial for the well-being of individuals and families. However, various factors such as chemotherapy, lifestyle changes, among others, may lead to a decline in female fertility, thus emphasizing the significance of preserving and restoring fertility. Stem cells, with their unique capacity for self-renewal and pluripotent differentiation, have made significant strides in areas such as ovarian tissue cryopreservation, in vitro culture of frozen-thawed ovarian tissue, and construction of ovarian-like organs. This review aims to summarize the latest findings in these fields, highlighting the pivotal role, mechanisms, and future prospects of stem cell technology in preserving and restoring female fertility. Additionally, the importance of interdisciplinary collaboration is underscored, as personalized stem cell therapy regimens tailored through interdisciplinary cooperation between reproductive medicine and stem cell fields hold promise in providing reliable solutions for the preservation and restoration of female fertility.

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探索干细胞技术：开辟女性生育能力保存和恢复的新途径。

女性的生育能力对个人和家庭的幸福至关重要。然而，化疗、生活方式的改变等各种因素都可能导致女性生育能力下降，因此，保持和恢复生育能力的意义就显得尤为重要。干细胞具有独特的自我更新和多能分化能力，在卵巢组织冷冻保存、冻融卵巢组织体外培养和卵巢类器官构建等领域取得了重大进展。本综述旨在总结这些领域的最新研究成果，强调干细胞技术在保存和恢复女性生育能力方面的关键作用、机制和未来前景。此外，还强调了跨学科合作的重要性，因为通过生殖医学和干细胞领域的跨学科合作定制的个性化干细胞治疗方案，有望为保存和恢复女性生育能力提供可靠的解决方案。

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