Synthesis, Antibacterial, and Antibiofilm Activity of Novel Sulfonyl-1H-1,2,3-triazolo-1H-imidazole-2-sulfonamides

Abstract

An efficient one-pot approach was proposed for the synthesis of novel sulfonyl-1H-1,2,3-triazolo-1H-imidazole-2-sulfonamides. The newly synthesized derivatives were screened for in vitro antibacterial inhibition potency against gram-positive strains. Among the tested compounds, N-({1-[(4-chlorophenyl)sulfonyl]-1H-1,2,3-triazol-4-yl}methyl)-1-methyl-1H-imidazole-2-sulfonamide and N-({1-[(4-cyanophenyl)sulfonyl]-1H-1,2,3-triazol-4-yl}methyl)-1-methyl-1H-imidazole-2-sulfonamide had a minimum inhibitory concentration (MIC) of 3.12 μg/mL against B. subtilis, which is two times higher than the normal streptomycin (6.25 μg/mL). It also had a MIC value of 6.25 μg/mL against S. aureus that was the same as the positive control. Also the antibiofilm profiles for the potent compounds showed that the active derivatives were not only very good at killing bacteria, but they were also very good at stopping the growth of B. subtilis biofilm.