Clinical Significance of Salivary Alpha-amylase Activity in Patients With Parkinson’s Disease

IF 1 Q4 GERONTOLOGY Ageing International Pub Date : 2023-12-11 DOI:10.1007/s12126-023-09538-5

Yui Mukaiyama, Mariko Inoue, Nichika Sumitomo, Noriko Kawazoe, Takayuki Tsuchihashi, Harunobu Shima, Takao Mitsui

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Abstract

Salivary alpha-amylase (sAA) is known as a stress indicator for the general adult population. However, its clinical significance has not been established in patients with neurodegenerative diseases. The subjects consisted of the PD group (n = 146), the control (C) group (n = 109) and the age-matched control (AC) group (n = 79). We explored what clinical indicators are associated with sAA in patients with Parkinson’s disease (PD). Results of factor analysis and stepwise multiple linear regression analysis demonstrated that NRS remained as the only factor related to sAA (p < 0.05). However, sAA was strictly related to age in the two control groups (p < 0.01). There was no significant difference in sAA between the PD and AC groups (p < 0.05). The results indicated that sAA could be an indicator of mental stress in patients with PD. In contrast, in the C group, sAA seemed to be mainly influenced by sympathetic tone associated with ageing.

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帕金森病患者唾液中α-淀粉酶活性的临床意义

众所周知，唾液α-淀粉酶（sAA）是普通成年人的压力指标。然而，它对神经退行性疾病患者的临床意义尚未确定。研究对象包括帕金森病组（146 人）、对照组（109 人）和年龄匹配对照组（79 人）。我们探讨了哪些临床指标与帕金森病（PD）患者的 sAA 相关。因子分析和逐步多元线性回归分析的结果表明，NRS仍是唯一与sAA相关的因子（p < 0.05）。然而，在两个对照组中，sAA与年龄密切相关（p <0.01）。PD组和AC组的sAA无明显差异（p <0.05）。结果表明，sAA 可以作为帕金森病患者精神压力的指标。相比之下，C 组的 sAA 似乎主要受与衰老相关的交感神经张力的影响。

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来源期刊

Ageing International GERONTOLOGY-

CiteScore

2.70

自引率

6.70%

发文量

期刊介绍： As a quarterly peer-reviewed journal that has existed for over three decades, Ageing International serves all professionals who deal with complex ageing issues. The journal is dedicated to improving the life of ageing populations worldwide through providing an intellectual forum for communicating common concerns, exchanging analyses and discoveries in scientific research, crystallizing significant issues, and offering recommendations in ageing-related service delivery and policy making. Besides encouraging the submission of high-quality research and review papers, Ageing International seeks to bring together researchers, policy analysts, and service program administrators who are committed to reducing the ''implementation gap'' between good science and effective service, between evidence-based protocol and culturally suitable programs, and between unique innovative solutions and generalizable policies. For significant issues that are common across countries, Ageing International will organize special forums for scholars and investigators from different disciplines to present their regional perspectives as well as to provide more comprehensive analysis. The editors strongly believe that such discourse has the potential to foster a wide range of coordinated efforts that will lead to improvements in the quality of life of older persons worldwide. Abstracted and Indexed in: ABI/INFORM, Academic OneFile, Academic Search, CSA/Proquest, Current Abstracts, EBSCO, Ergonomics Abstracts, Expanded Academic, Gale, Google Scholar, Health Reference Center Academic, OCLC, PsychINFO, PsyARTICLES, SCOPUS, Social Science Abstracts, and Summon by Serial Solutions.